Timp1 tissue inhibitor of metalloproteinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Timp1provided by MGI
Official Full Name: tissue inhibitor of metalloproteinase 1provided by MGI
Primary source: MGI:MGI:98752
See related: Ensembl:ENSMUSG00000001131 AllianceGenome:MGI:98752
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EPA; Clgi; Timp; TIMP-1; TPA-S1
Summary: Predicted to enable several functions, including cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Located in basement membrane. Is expressed in several structures, including alimentary system; early conceptus; hindlimb cartilage condensation; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 113.3), adrenal adult (RPKM 13.6) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.3; X 16.38 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (20736524..20740972)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (20870166..20874737)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Timp1 Deletion Induces Anxiety-like Behavior in Mice.
Title: Timp1 Deletion Induces Anxiety-like Behavior in Mice.
Host response during unresolved urinary tract infection alters female mammary tissue homeostasis through collagen deposition and TIMP1.
Title: Host response during unresolved urinary tract infection alters female mammary tissue homeostasis through collagen deposition and TIMP1.
Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection.
Title: Host factor TIMP1 sustains long-lasting myeloid-biased hematopoiesis after severe infection.
RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-kappaB signaling pathway.
Title: RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-κB signaling pathway.
The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
Title: The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.
Title: CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice.
siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
Title: siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
Title: Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1.
Histological characteristics of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in asthmatic murine model during A(H1N1)pdm09 infection.
Title: Histological characteristics of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in asthmatic murine model during A(H1N1)pdm09 infection.
Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.
Title: Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression.

Submit: New GeneRIF Correction See all GeneRIFs (121)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (4) 1 citation

General gene information

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Markers

Timp1 (e-PCR), detects polymorphism
- UniSTS:265760

Timp1 (e-PCR), detects polymorphism
- UniSTS:259383

AA957593 (e-PCR)
- UniSTS:248146

Timp1 (e-PCR), detects polymorphism
- UniSTS:265629

PMC115071P1 (e-PCR)
- UniSTS:270284

Timp (e-PCR), detects polymorphism
- UniSTS:144625

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-A	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to peptide	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catalytic activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metallopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of trophoblast cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metalloproteinase inhibitor 1

Names: TPA-induced protein; collagenase inhibitor 16C8 fibroblast; erythroid-potentiating activity; tissue inhibitor of metalloproteinases 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044384.2 → NP_001037849.1 metalloproteinase inhibitor 1 isoform a precursor

See identical proteins and their annotated locations for NP_001037849.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AL671885

Consensus CDS

CCDS30046.1

UniProtKB/Swiss-Prot

P12032, P20064, Q61720

Related

ENSMUSP00000009530.5, ENSMUST00000009530.5

Conserved Domains (1) summary

smart00206
Location:25 → 199

NTR; Tissue inhibitor of metalloproteinase family
NM_001294280.3 → NP_001281209.1 metalloproteinase inhibitor 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (b).

Source sequence(s)

AL671885

Conserved Domains (1) summary

cl02512
Location:1 → 131

NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
NM_001426018.1 → NP_001412947.1 metalloproteinase inhibitor 1 isoform b

Status: VALIDATED

Source sequence(s)

AL671885
NM_001426019.1 → NP_001412948.1 metalloproteinase inhibitor 1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AL671885
NM_001426020.1 → NP_001412949.1 metalloproteinase inhibitor 1 isoform c precursor

Status: VALIDATED

Source sequence(s)

AL671885
NM_011593.3 → NP_035723.2 metalloproteinase inhibitor 1 isoform a precursor

See identical proteins and their annotated locations for NP_035723.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AL671885

Consensus CDS

CCDS30046.1

UniProtKB/Swiss-Prot

P12032, P20064, Q61720

Related

ENSMUSP00000110999.4, ENSMUST00000115342.10

Conserved Domains (1) summary

smart00206
Location:25 → 199

NTR; Tissue inhibitor of metalloproteinase family