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    Ak9 adenylate kinase 9 [ Mus musculus (house mouse) ]

    Gene ID: 633979, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ak9provided by MGI
    Official Full Name
    adenylate kinase 9provided by MGI
    Primary source
    MGI:MGI:2685080
    See related
    Ensembl:ENSMUSG00000091415 AllianceGenome:MGI:2685080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akd1; Akd2; Gm234; Gm7127
    Summary
    Predicted to enable (d)CMP kinase activity; UMP kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in CDP biosynthetic process and UDP biosynthetic process. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; lung; and rib. Used to study normal pressure hydrocephalus. Human ortholog(s) of this gene implicated in spermatogenic failure 89. Orthologous to human AK9 (adenylate kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 5.1) See more
    Orthologs
    human all
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    Genomic context

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    See Ak9 in Genome Data Viewer
    Location:
    10 B1; 10 22.23 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41179433..41309565)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41303432..41433569)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32411 Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene predicted gene, 25526 Neighboring gene STARR-seq mESC enhancer starr_26444 Neighboring gene STARR-seq mESC enhancer starr_26445 Neighboring gene STARR-seq mESC enhancer starr_26446 Neighboring gene STARR-seq mESC enhancer starr_26447 Neighboring gene sperm specific antigen 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8331 Neighboring gene STARR-seq mESC enhancer starr_26448 Neighboring gene ClpB caseinolytic peptidase B homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_26449 Neighboring gene predicted gene, 25626 Neighboring gene STARR-seq mESC enhancer starr_26450 Neighboring gene STARR-positive B cell enhancer ABC_E2321 Neighboring gene predicted gene, 53622 Neighboring gene zinc finger and BTB domain containing 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus. Yang HW, et al. Proc Natl Acad Sci U S A, 2023 Dec 19. PMID 38100419, Free PMC Article
    2. Adenylate kinase 9 is essential for sperm function and male fertility in mammals. O'Callaghan E, et al. Proc Natl Acad Sci U S A, 2023 Oct 17. PMID 37812723, Free PMC Article
    3. Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis. Sha Y, et al. EBioMedicine, 2023 Oct. PMID 37713809, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus.
      Title: A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus.
    2. Adenylate kinase 9 is essential for sperm function and male fertility in mammals.
      Title: Adenylate kinase 9 is essential for sperm function and male fertility in mammals.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (d)CMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside monophosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase 9
    Names
    adenylate kinase domain containing 1
    adenylate kinase domain containing 2
    NP_001357742.1
    XP_006513002.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370813.1 → NP_001357742.1  adenylate kinase 9

      Status: VALIDATED

      Source sequence(s)
      AC122332, AC153360
      UniProtKB/Swiss-Prot
      G3UYQ4
      Related
      ENSMUSP00000134177.3, ENSMUST00000173494.4
      Conserved Domains (3) summary
      cd01428
      Location:1381 → 1553
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:34 → 286
      adk; adenylate kinase
      cl00909
      Location:926 → 956
      Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      41179433..41309565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512939.4 → XP_006513002.1  adenylate kinase 9 isoform X1

      See identical proteins and their annotated locations for XP_006513002.1

      UniProtKB/Swiss-Prot
      G3UYQ4
      Conserved Domains (3) summary
      cd01428
      Location:1381 → 1553
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:34 → 286
      adk; adenylate kinase
      cl00909
      Location:926 → 956
      Ribosomal_L24e_L24; Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3UYQ4.2 GenPept UniProtKB/Swiss-Prot:G3UYQ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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