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    Cluh clustered mitochondria homolog [ Mus musculus (house mouse) ]

    Gene ID: 74148, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cluhprovided by MGI
    Official Full Name
    clustered mitochondria homologprovided by MGI
    Primary source
    MGI:MGI:1921398
    See related
    Ensembl:ENSMUSG00000020741 AllianceGenome:MGI:1921398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa0664; mKIAA0664; 1300001I01Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in intracellular distribution of mitochondria and mitochondrion organization. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; musculature; and naris. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 48.6), adrenal adult (RPKM 47.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cluh in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74539707..74561680)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74648881..74670854)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E7014 Neighboring gene STARR-seq mESC enhancer starr_29957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:74369680-74369789 Neighboring gene STARR-seq mESC enhancer starr_29960 Neighboring gene STARR-seq mESC enhancer starr_29961 Neighboring gene STARR-seq mESC enhancer starr_29962 Neighboring gene predicted gene, 50590 Neighboring gene coiled-coil domain containing 92B Neighboring gene STARR-positive B cell enhancer ABC_E3971 Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 Neighboring gene STARR-seq mESC enhancer starr_29966 Neighboring gene predicted gene, 24211

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice. Ralevski A, et al. Cell Mol Life Sci, 2022 Jun 2. PMID 35652974, Free PMC Article
    2. Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA. Singh S, et al. Basic Res Cardiol, 2023 Nov 3. PMID 37923788
    3. CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy. Pla-Martín D, et al. EMBO J, 2020 May 4. PMID 32149416, Free PMC Article
    4. CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy. Zaninello M, et al. Sci Adv, 2024 May 31. PMID 38809982, Free PMC Article
    5. CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. Schatton D, et al. J Cell Biol, 2017 Mar 6. PMID 28188211, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy.
      Title: CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy.
    2. Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
      Title: Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.
    3. Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
      Title: Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
    4. CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.
      Title: CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular distribution of mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular distribution of mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    clustered mitochondria protein homolog
    Names
    clustered mitochondria (cluA/CLU1) homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081158.3 → NP_001074627.1  clustered mitochondria protein homolog isoform 1

      See identical proteins and their annotated locations for NP_001074627.1

      Status: VALIDATED

      Source sequence(s)
      AL607024, AL645971
      Consensus CDS
      CCDS36223.1
      UniProtKB/TrEMBL
      A0A0R4J140, Z4YLI8
      Related
      ENSMUSP00000090593.6, ENSMUST00000092915.12
      Conserved Domains (6) summary
      sd00006
      Location:1062 → 1088
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:809 → 988
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:394 → 614
      CLU; Clustered mitochondria
      pfam13374
      Location:1061 → 1100
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1140 → 1217
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:104 → 177
      CLU_N; Mitochondrial function, CLU-N-term

    2. NM_001368711.1 → NP_001355640.1  clustered mitochondria protein homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL607024, AL645971
      UniProtKB/Swiss-Prot
      A8Y5E2, Q3U014, Q3U4M5, Q3V3Q8, Q505Q6, Q5SW19, Q6GQX1, Q6PAT1, Q8CHD9
      UniProtKB/TrEMBL
      Z4YLI8
      Conserved Domains (5) summary
      sd00006
      Location:1024 → 1050
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1104 → 1179
      TPR_12; Tetratricopeptide repeat
      pfam12807
      Location:769 → 950
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:356 → 576
      CLU; Clustered mitochondria
      pfam15044
      Location:66 → 139
      CLU_N; Mitochondrial function, CLU-N-term

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74539707..74561680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314805.3 → XP_017170294.1  clustered mitochondria protein homolog isoform X1

      UniProtKB/TrEMBL
      Z4YLI8
      Conserved Domains (5) summary
      sd00006
      Location:1061 → 1087
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1141 → 1216
      TPR_12; Tetratricopeptide repeat
      pfam12807
      Location:806 → 987
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:394 → 614
      CLU; Clustered mitochondria
      pfam15044
      Location:104 → 177
      CLU_N; Mitochondrial function, CLU-N-term

    2. XM_006534353.4 → XP_006534416.1  clustered mitochondria protein homolog isoform X2

      See identical proteins and their annotated locations for XP_006534416.1

      UniProtKB/Swiss-Prot
      A8Y5E2, Q3U014, Q3U4M5, Q3V3Q8, Q505Q6, Q5SW19, Q6GQX1, Q6PAT1, Q8CHD9
      UniProtKB/TrEMBL
      Z4YLI8
      Conserved Domains (5) summary
      sd00006
      Location:1024 → 1050
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1104 → 1179
      TPR_12; Tetratricopeptide repeat
      pfam12807
      Location:769 → 950
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:356 → 576
      CLU; Clustered mitochondria
      pfam15044
      Location:66 → 139
      CLU_N; Mitochondrial function, CLU-N-term
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SW19.2 GenPept UniProtKB/Swiss-Prot:Q5SW19

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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