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    Trim41 tripartite motif-containing 41 [ Mus musculus (house mouse) ]

    Gene ID: 211007, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Trim41provided by MGI
    Official Full Name
    tripartite motif-containing 41provided by MGI
    Primary source
    MGI:MGI:2384814
    See related
    Ensembl:ENSMUSG00000040365 AllianceGenome:MGI:2384814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RINCK
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to muramyl dipeptide; defense response to symbiont; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in nucleolus. Predicted to be active in nuclear body. Orthologous to human TRIM41 (tripartite motif containing 41). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 35.3), adrenal adult (RPKM 16.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim41 in Genome Data Viewer
    Location:
    11 B1.2; 11 28.78 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48697230..48709026, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (48806403..48818199, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene receptor for activated C kinase 1 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene STARR-positive B cell enhancer ABC_E11476 Neighboring gene STARR-positive B cell enhancer ABC_E1822 Neighboring gene nuclear encoded tRNA valine 7 (anticodon CAC) Neighboring gene nuclear encoded tRNA glycine 1 (anticodon ACC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO. Yu Z, et al. Signal Transduct Target Ther, 2021 Feb 28. PMID 33640899, Free PMC Article
    2. Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice. Oura S, et al. PLoS Genet, 2022 Jun. PMID 35648791, Free PMC Article
    3. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. Chen D, et al. J Biol Chem, 2007 Nov 16. PMID 17893151
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice.
      Title: Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice.
    2. RINCK is an E3 ligase that specifically recognizes the C1 domain of PKC isoforms
      Title: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28280

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to muramyl dipeptide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM41
    Names
    RING-type E3 ubiquitin transferase TRIM41
    tripartite motif-containing protein 41
    NP_663352.2
    XP_006532821.1
    XP_006532822.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145377.2 → NP_663352.2  E3 ubiquitin-protein ligase TRIM41

      Status: VALIDATED

      Source sequence(s)
      AL645849, BC041780
      Consensus CDS
      CCDS36138.1
      UniProtKB/Swiss-Prot
      Q5NCC3
      Related
      ENSMUSP00000037055.8, ENSMUST00000047145.14
      Conserved Domains (5) summary
      cd00021
      Location:226 → 263
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd13741
      Location:432 → 630
      SPRY_PRY_TRIM41; PRY/SPRY domain in tripartite motif-binding protein 41 (TRIM41)
      pfam01442
      Location:263 → 374
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cl00459
      Location:286 → 381
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl17238
      Location:20 → 48
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      48697230..48709026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532758.3 → XP_006532821.1  E3 ubiquitin-protein ligase TRIM41 isoform X1

      Conserved Domains (4) summary
      cd16602
      Location:16 → 48
      RING-HC_TRIM41_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM41, TRIM52 and similar proteins
      pfam01442
      Location:263 → 388
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      cd19762
      Location:225 → 268
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
      cl02614
      Location:432 → 489
      SPRY; SPRY domain

    2. XM_006532759.5 → XP_006532822.1  E3 ubiquitin-protein ligase TRIM41 isoform X2

      Conserved Domains (2) summary
      cd13741
      Location:196 → 394
      SPRY_PRY_TRIM41; PRY/SPRY domain in tripartite motif-binding protein 41 (TRIM41)
      pfam01442
      Location:33 → 152
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RNA

    1. XR_004936899.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NCC3.1 GenPept UniProtKB/Swiss-Prot:Q5NCC3

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