Ly6m lymphocyte antigen 6 family member M [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ly6mprovided by MGI
Official Full Name: lymphocyte antigen 6 family member Mprovided by MGI
Primary source: MGI:MGI:1914288
See related: Ensembl:ENSMUSG00000063522 AllianceGenome:MGI:1914288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010109I03Rik
Summary: Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway and regulation of neurotransmitter receptor activity. Predicted to be active in plasma membrane. Is expressed in adrenal medulla. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 159.6), small intestine adult (RPKM 144.6) and 3 other tissues See more
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Genomic context

Location:: 15 D3; 15 34.29 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74750185..74753553, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74878336..74881704, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intectin is a novel small intestine-specific glycosylphosphatidylinositol-anchored protein that accelerates apoptosis of intestinal epithelial cells
Title: Intectin, a novel small intestine-specific glycosylphosphatidylinositol-anchored protein, accelerates apoptosis of intestinal epithelial cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

px-31f3 (e-PCR)
- UniSTS:257585

NoName (e-PCR)
- UniSTS:493199

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: intectin

Names: lymphocyte antigen 6 complex, locus M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025929.2 → NP_080205.1 intectin precursor

See identical proteins and their annotated locations for NP_080205.1

Status: VALIDATED

Source sequence(s)

AK018552, AK038164

Consensus CDS

CCDS27537.1

UniProtKB/TrEMBL

Q14B14, Q9CQ11

Related

ENSMUSP00000076264.5, ENSMUST00000077004.6

Conserved Domains (1) summary

cd00117
Location:21 → 90

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...