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    Cyp2ab1 cytochrome P450, family 2, subfamily ab, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 224044, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cyp2ab1provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily ab, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:3644957
    See related
    Ensembl:ENSMUSG00000022818 AllianceGenome:MGI:3644957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG224044; F730023N20
    Summary
    Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in ganglia; male reproductive gland or organ; medulla oblongata basal plate mantle layer; thyroid gland; and ventral grey horn. Orthologous to human CYP2AB1P (cytochrome P450 family 2 subfamily AB member 1, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Cyp2ab1 in Genome Data Viewer
    Location:
    16 A3; 16 12.41 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20127137..20144154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20308387..20325404, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene MAP6 domain containing 1 Neighboring gene predicted gene, 49566 Neighboring gene presenilin associated, rhomboid-like Neighboring gene ATP-binding cassette, sub-family C member 5 Neighboring gene STARR-seq mESC enhancer starr_40320 Neighboring gene STARR-seq mESC enhancer starr_40322 Neighboring gene STARR-seq mESC enhancer starr_40323 Neighboring gene predicted gene, 41432

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily ab, polypeptide 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183158.3 → NP_898981.2  cytochrome P450, family 2, subfamily ab, polypeptide 1

      See identical proteins and their annotated locations for NP_898981.2

      Status: VALIDATED

      Source sequence(s)
      AC154526, AK089408, BC138088
      Consensus CDS
      CCDS49791.1
      UniProtKB/TrEMBL
      E9PZ31
      Related
      ENSMUSP00000156220.2, ENSMUST00000182508.9
      Conserved Domains (1) summary
      cl41757
      Location:1 → 266
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20127137..20144154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316953.2 → XP_017172442.1  cytochrome P450, family 2, subfamily ab, polypeptide 1 isoform X2

      Conserved Domains (1) summary
      pfam00067
      Location:24 → 423
      p450; Cytochrome P450

    2. XM_017316954.3 → XP_017172443.1  cytochrome P450, family 2, subfamily ab, polypeptide 1 isoform X3

      Conserved Domains (1) summary
      pfam00067
      Location:18 → 346
      p450; Cytochrome P450

    3. XM_017316952.3 → XP_017172441.1  cytochrome P450, family 2, subfamily ab, polypeptide 1 isoform X1

      UniProtKB/TrEMBL
      S4R196
      Related
      ENSMUSP00000138133.2, ENSMUST00000182741.2
      Conserved Domains (1) summary
      pfam00067
      Location:18 → 446
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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