U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Det Deterin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42077, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Detprovided by FlyBase
    Official Full Name
    Deterinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264291
    Locus tag
    Dmel_CG12265
    See related
    AllianceGenome:FB:FBgn0264291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12265; det; Dmel\CG12265; scpo; svn
    Summary
    Involved in several processes, including cytoskeleton-dependent cytokinesis; meiotic chromosome segregation; and spindle organization. Located in cytoplasm; kinetochore; and spindle midzone. Part of chromosome passenger complex. Is expressed in several structures, including embryonic brain; female germline cell; and gonad. Human ortholog(s) of this gene implicated in prostate cancer; pulmonary hypertension; and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Det in Genome Data Viewer
    Location:
    89F1-89F1; 3-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17149667..17150455)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12975389..12976177)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TweedleW Neighboring gene mann-cup Neighboring gene uncharacterized protein Neighboring gene Single-strand-selective monofunctional uracil-DNA glycosylase Neighboring gene Mucin related 89F

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. BIRinging chromosomes through cell division--and survivin' the experience. Reed JC, et al. Cell, 2000 Sep 1. PMID 11007472
    2. Deterin, a new inhibitor of apoptosis from Drosophila melanogaster. Jones G, et al. J Biol Chem, 2000 Jul 21. PMID 10764741
    3. The chromosomal passenger complex activates Polo kinase at centromeres. Carmena M, et al. PLoS Biol, 2012 Jan. PMID 22291575, Free PMC Article
    4. Regulation of survivin protein stability by USP35 is evolutionarily conserved. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 15. PMID 34438346
    5. Somatic cell encystment promotes abscission in germline stem cells following a regulated block in cytokinesis. Lenhart KF, et al. Dev Cell, 2015 Jul 27. PMID 26143993, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiosis I cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis II cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromosome passenger complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in meiotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    deterin
    Names
    CG12265-PA
    Det-PA
    dSurvivin
    scapolo
    survivin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17149667..17150455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142351.4 → NP_650608.1  deterin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEM2
      Related
      FBpp0082849
      Conserved Domains (1) summary
      pfam00653
      Location:31 → 101
      BIR; Inhibitor of Apoptosis domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEM2 Q9VEM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous