ppk19 pickpocket 19 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ppk19provided by FlyBase
Official Full Name: pickpocket 19provided by FlyBase
Primary source: FLYBASE:FBgn0039679
Locus tag: Dmel_CG18287
See related: AllianceGenome:FB:FBgn0039679
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18287; Dmel\CG18287; Ppk19; PPK19
Summary: Enables mechanosensitive monoatomic cation channel activity; pH-gated monoatomic ion channel activity; and sodium channel activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; salt aversion; and sensory perception of salty taste. Part of sodium channel complex. Is active in plasma membrane. Is expressed in several structures, including external sensory organ; primary tracheal branch; segment of leg; tracheal tip cell; and wing margin. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29672456..29674223)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25498178..25499945)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables mechanosensitive monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables pH-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liquid clearance, open tracheal system	NAS Non-traceable Author Statement more info	PubMed
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salt aversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of salty taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of sodium channel complex	IPI Inferred from Physical Interaction more info	PubMed

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