SH3BGRL3 SH3 domain binding glutamate rich protein like 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SH3BGRL3provided by HGNC
Official Full Name: SH3 domain binding glutamate rich protein like 3provided by HGNC
Primary source: HGNC:HGNC:15568
See related: Ensembl:ENSG00000142669 MIM:615679; AllianceGenome:HGNC:15568
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIP-B1; SH3BP-1; HEL-S-297
Summary: Involved in cytoskeleton organization. Located in cytosol; nuclear body; and ruffle membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in appendix (RPKM 140.1), colon (RPKM 114.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (26280086..26281522)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (26117570..26119006)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (26606577..26608013)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.
Title: SH3BGRL3 binds to myosin 1c in a calcium dependent manner and modulates migration in the MDA-MB-231 cell line.
SH3BGRL3, transcribed by STAT3, facilitates glioblastoma tumorigenesis by activating STAT3 signaling.
Title: SH3BGRL3, transcribed by STAT3, facilitates glioblastoma tumorigenesis by activating STAT3 signaling.
SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.
Title: SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.
SH3BGRL3 is a novel urinary biomarker for urothelial carcinoma. Evaluation of SH3BGRL3 expression status may identify a subset of patients with urothelial carcinoma for cotargeting candidates in the design of EGFR-based cancer therapies.
Title: SH3BGRL3 Protein as a Potential Prognostic Biomarker for Urothelial Carcinoma: A Novel Binding Partner of Epidermal Growth Factor Receptor.
SH3BGRL3 may function as a regulator in all-trans retinoic acid-induced pathway
Title: NMR structure and regulated expression in APL cell of human SH3BGRL3.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235062

RH102252 (e-PCR)
- UniSTS:96586

RH79742 (e-PCR)
- UniSTS:87944

RH91491 (e-PCR)
- UniSTS:86925

RH80614 (e-PCR)
- UniSTS:89305

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in ruffle membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: SH3 domain-binding glutamic acid-rich-like protein 3

Names: SH3 domain binding glutamic acid-rich protein like 3; SH3 domain-binding protein 1; SH3BGRL3-like protein; TNF inhibitory protein; TNF inhibitory protein B1; epididymis secretory protein Li 297; epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.