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    pHCl-2 pH-sensitive chloride channel 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pHCl-2provided by FlyBase
    Official Full Name
    pH-sensitive chloride channel 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039840
    Locus tag
    Dmel_CG11340
    See related
    AllianceGenome:FB:FBgn0039840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11340; CT5896; Dmel\CG11340; hodor; Lcch-100C; lincRNA.914; pHCL-2
    Summary
    Enables excitatory extracellular ligand-gated monoatomic ion channel activity; pH-gated chloride channel activity; and zinc ion sensor activity. Involved in several processes, including cellular response to zinc ion; chloride transmembrane transport; and positive regulation of signal transduction. Located in apical plasma membrane; bounding membrane of organelle; and brush border membrane. Part of transmembrane transporter complex. Is expressed in several structures, including Malpighian tubule; Malpighian tubule Type I cell; adult brain; gut section; and larval midgut enterocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See pHCl-2 in Genome Data Viewer
    Location:
    100C1-100C1; 3-102 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31300918..31305384, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27128211..27131106, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 5 Neighboring gene pickpocket 24 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46118 Neighboring gene gasket

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The orphan pentameric ligand-gated ion channel pHCl-2 is gated by pH and regulates fluid secretion in Drosophila Malpighian tubules. Feingold D, et al. J Exp Biol, 2016 Sep 1. PMID 27358471
    2. Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria. Dent JA. J Mol Evol, 2006 May. PMID 16586016
    3. Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion. Witte I, et al. J Neurochem, 2002 Nov. PMID 12390512
    4. Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster. Remnant EJ, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172217, Free PMC Article
    5. An intestinal zinc sensor regulates food intake and developmental growth. Redhai S, et al. Nature, 2020 Apr. PMID 32269334, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identification of Hodor, an ionotropic receptor in enterocytes that sustains larval development, particularly in nutrient-scarce conditions; experiments in Xenopus oocytes and flies indicate that Hodor is a pH-sensitive, zinc-gated chloride channel that mediates a previously unrecognized dietary preference for zinc
      Title: An intestinal zinc sensor regulates food intake and developmental growth.
    2. Ligand-gated chloride channels have established roles in inhibitory neurotransmission in the nervous systems of vertebrates and invertebrates. Paradoxically, expression databases in Drosophila melanogaster have revealed that three uncharacterized ligand-gated chloride channel subunits, CG7589, CG6927, and CG11340, are highly expressed in nonneuronal tissues.
      Title: Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pH-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin-like growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of renal water transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transmembrane transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pH-sensitive chloride channel 2
    Names
    CG11340-PA
    CG11340-PB
    glycine-gated chloride channel-like
    hold on, don't rush
    pHCl-2-PA
    pHCl-2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31300918..31305384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316541.1 → NP_001303470.1  pH-sensitive chloride channel 2, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E3CTP9, Q9V9Y4
      Conserved Domains (1) summary
      TIGR00860
      Location:46 → 522
      LIC; Cation transporter family protein

    2. NM_143604.3 → NP_651861.1  pH-sensitive chloride channel 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E3CTP9, Q9V9Y4
      Related
      FBpp0085128
      Conserved Domains (1) summary
      TIGR00860
      Location:46 → 522
      LIC; Cation transporter family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9Y4.1 Q9V9Y4

    Gene LinkOut

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