PLCB2 phospholipase C beta 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLCB2provided by HGNC
Official Full Name: phospholipase C beta 2provided by HGNC
Primary source: HGNC:HGNC:9055
See related: Ensembl:ENSG00000137841 MIM:604114; AllianceGenome:HGNC:9055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PLC-beta-2
Summary: The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]
Expression: Broad expression in spleen (RPKM 26.9), bone marrow (RPKM 19.8) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q15.1

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (40284256..40307935, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (38091173..38114815, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (40580110..40600136, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLCbeta2 Promotes VEGF-Induced Vascular Permeability.
Title: PLCβ2 Promotes VEGF-Induced Vascular Permeability.
Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals.
Title: Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals.
High PLCB2 expression is associated with breast cancer.
Title: Ectopic expression of PLC-β2 in non-invasive breast tumor cells plays a protective role against malignant progression and is correlated with the deregulation of miR-146a.
this work adds substantial information about the role of PLC-beta2 in invasive breast tumors, demonstrating that its up-regulation in cells with a basal-B triple-negative phenotype is sufficient to down-modulate the expression of surface antigens crucial for malignancy and to reduce the number of cells with a stem-like phenotype.
Title: Up-modulation of PLC-β2 reduces the number and malignancy of triple-negative breast tumor cells with a CD133(+)/EpCAM(+) phenotype: a promising target for preventing progression of TNBC.
Hypoxia modulates the expression of PLC-beta-2 in breast tumor cells in a phenotype-related manner, since a decrease of the protein was observed in the BT-474 and MCF7 cell lines while an increase was revealed in MDA-MB-231 cells as a consequence of low oxygen availability.
Title: PLC-β2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential.
Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 activation and neutrophil arrest in vivo
Title: Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.
Neuropeptide Y decreased PLCB2 expression in HUVECs.
Title: Neuropeptide Y reduces the expression of PLCB2, PLCD1 and selected PLC genes in cultured human endothelial cells.
high expression of CD133 in triple-negative breast cancer (TNBC)-derived cells correlates with high invasive potential; aggressive properties of CD133high cells are mitigated by PLC-beta2 which down-modulates expression of CD133 and may play a role in preventing metastatic progression of CD133 positive TNBC
Title: In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness.
WDR26 functions as a scaffolding protein to promote PLCbeta2 membrane translocation and interaction with Gbetagamma, thereby enhancing PLCbeta2 activation in leukocytes.
Title: WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.
In this study, we show that staphylococcal enterotoxin B activates a Galphaq and PLCbeta2-dependent pathway in human T cells
Title: Superantigen-induced steroid resistance depends on activation of phospholipase Cβ2.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies five new schizophrenia loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	PLC-beta activation and intracellular Ca2+ release are required for HIV-1 mediated Rac-1 activation and membrane fusion via the G-alpha(q/11) family of G proteins	PubMed
	env	HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells	PubMed
Tat	tat	Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat	PubMed
	tat	HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-30151 (e-PCR)
- UniSTS:25104

MARC_15317-15318:1017258886:1 (e-PCR)
- UniSTS:267810

MARC_15317-15318:1031933595:3 (e-PCR)
- UniSTS:267810

PLCB2_382 (e-PCR)
- UniSTS:277589

D15S994 (e-PCR)
- UniSTS:23656

G15920 (e-PCR)
- UniSTS:81818

SHGC-154601 (e-PCR)
- UniSTS:183715

D15S1327 (e-PCR)
- UniSTS:66533

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol phospholipase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol phospholipase C activity	TAS Traceable Author Statement more info
enables phospholipase C activity	TAS Traceable Author Statement more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of G-protein beta/gamma-subunit complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Names: phosphoinositide phospholipase C-beta-2

NP_001271226.1

EC 3.1.4.11

NP_001271227.1

EC 3.1.4.11

NP_001271228.1

EC 3.1.4.11

NP_004564.2

EC 3.1.4.11

XP_016877803.1

EC 3.1.4.11

XP_016877806.1

EC 3.1.4.11

XP_016877808.1

EC 3.1.4.11

XP_047288623.1

EC 3.1.4.11

XP_047288624.1

EC 3.1.4.11

XP_047288625.1

EC 3.1.4.11

XP_047288626.1

EC 3.1.4.11

XP_047288627.1

EC 3.1.4.11

XP_047288628.1

EC 3.1.4.11

XP_047288629.1

EC 3.1.4.11

XP_047288630.1

EC 3.1.4.11

XP_047288631.1

EC 3.1.4.11

XP_047288632.1

EC 3.1.4.11

XP_047288633.1

EC 3.1.4.11

XP_047288634.1

EC 3.1.4.11

XP_047288635.1

EC 3.1.4.11

XP_047288636.1

EC 3.1.4.11

XP_047288637.1

EC 3.1.4.11

XP_047288638.1

EC 3.1.4.11

XP_047288639.1

EC 3.1.4.11

XP_047288640.1

EC 3.1.4.11

XP_047288641.1

EC 3.1.4.11

XP_047288642.1

EC 3.1.4.11

XP_047288643.1

EC 3.1.4.11

XP_047288644.1

EC 3.1.4.11

XP_047288645.1

EC 3.1.4.11

XP_054234164.1

EC 3.1.4.11

XP_054234165.1

EC 3.1.4.11

XP_054234166.1

EC 3.1.4.11

XP_054234167.1

EC 3.1.4.11

XP_054234168.1

EC 3.1.4.11

XP_054234169.1

EC 3.1.4.11

XP_054234170.1

EC 3.1.4.11

XP_054234171.1

EC 3.1.4.11

XP_054234172.1

EC 3.1.4.11

XP_054234173.1

EC 3.1.4.11

XP_054234174.1

EC 3.1.4.11

XP_054234175.1

EC 3.1.4.11

XP_054234176.1

EC 3.1.4.11

XP_054234177.1

EC 3.1.4.11

XP_054234178.1

EC 3.1.4.11

XP_054234179.1

EC 3.1.4.11

XP_054234180.1

EC 3.1.4.11

XP_054234181.1

EC 3.1.4.11

XP_054234182.1

EC 3.1.4.11

XP_054234183.1

EC 3.1.4.11

XP_054234184.1

EC 3.1.4.11

XP_054234185.1

EC 3.1.4.11

XP_054234186.1

EC 3.1.4.11

XP_054234187.1

EC 3.1.4.11

XP_054234188.1

EC 3.1.4.11

XP_054234189.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052867.1 RefSeqGene

Range

5039..25065

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001284297.2 → NP_001271226.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 2

See identical proteins and their annotated locations for NP_001271226.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AB209583, DA981116, M95678

Consensus CDS

CCDS61592.1

UniProtKB/Swiss-Prot

Q00722

UniProtKB/TrEMBL

Q59F77

Related

ENSP00000453975.1, ENST00000557821.5

Conserved Domains (8) summary

cd00275
Location:677 → 798

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08624
Location:311 → 645

PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2

PLN02228
Location:217 → 782

PLN02228; Phosphoinositide phospholipase C

cd13361
Location:17 → 144

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam08703
Location:974 → 1149

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:220 → 311

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cd16269
Location:1100 → 1110

GBP_C; coiled coil [structural motif]

cl20817
Location:990 → 1119

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001284298.2 → NP_001271227.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 3

See identical proteins and their annotated locations for NP_001271227.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AB209583, BC136467, DA981116

Consensus CDS

CCDS61591.1

UniProtKB/Swiss-Prot

Q00722

UniProtKB/TrEMBL

Q59F77

Related

ENSP00000411991.2, ENST00000456256.6

Conserved Domains (5) summary

cd00275
Location:681 → 802

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08624
Location:311 → 649

PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2

cd16209
Location:149 → 299

EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

pfam17787
Location:12 → 141

PH_14; PH domain

pfam08703
Location:963 → 1138

PLC-beta_C; PLC-beta C terminal
NM_001284299.2 → NP_001271228.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 4

See identical proteins and their annotated locations for NP_001271228.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC020658, BC009009, DA981116

Consensus CDS

CCDS73704.1

UniProtKB/TrEMBL

Q9BVT6

Related

ENSP00000444652.2, ENST00000543785.3

Conserved Domains (1) summary

cd13361
Location:17 → 144

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
NM_004573.3 → NP_004564.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1

See identical proteins and their annotated locations for NP_004564.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB209583, BU147302, DA981116, M95678

Consensus CDS

CCDS42020.1

UniProtKB/Swiss-Prot

A8K6J2, B9EGH5, Q00722

Related

ENSP00000260402.3, ENST00000260402.8

Conserved Domains (8) summary

cd00275
Location:681 → 802

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08624
Location:311 → 649

PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2

PLN02228
Location:217 → 786

PLN02228; Phosphoinositide phospholipase C

cd13361
Location:17 → 144

PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain

pfam08703
Location:978 → 1153

PLC-beta_C; PLC-beta C terminal

pfam09279
Location:220 → 311

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cd16269
Location:1104 → 1114

GBP_C; coiled coil [structural motif]

cl20817
Location:994 → 1123

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

40284256..40307935 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432684.1 → XP_047288640.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X21
XM_047432682.1 → XP_047288638.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X19
XM_047432680.1 → XP_047288636.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X17
XM_047432679.1 → XP_047288635.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X15
XM_047432686.1 → XP_047288642.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X23
XM_047432685.1 → XP_047288641.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X22
XM_047432681.1 → XP_047288637.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X18
XM_047432683.1 → XP_047288639.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X20
XM_017022319.3 → XP_016877808.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X16
XM_047432678.1 → XP_047288634.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X14
XM_047432677.1 → XP_047288633.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X13
XM_047432675.1 → XP_047288631.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X11
XM_047432672.1 → XP_047288628.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X8
XM_047432668.1 → XP_047288624.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3
XM_047432676.1 → XP_047288632.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X12
XM_047432673.1 → XP_047288629.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X9
XM_047432670.1 → XP_047288626.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6
XM_047432669.1 → XP_047288625.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5
XM_047432674.1 → XP_047288630.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X10
XM_047432671.1 → XP_047288627.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7
XM_047432667.1 → XP_047288623.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2
XM_017022317.3 → XP_016877806.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4
XM_017022314.3 → XP_016877803.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
XM_047432687.1 → XP_047288643.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X24

UniProtKB/TrEMBL

Q59F77
XM_047432688.1 → XP_047288644.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X25

UniProtKB/TrEMBL

Q59F77
XM_047432689.1 → XP_047288645.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X26

RNA

XR_007064458.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

38091173..38114815 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054378209.1 → XP_054234184.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X21
XM_054378207.1 → XP_054234182.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X19
XM_054378205.1 → XP_054234180.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X17
XM_054378203.1 → XP_054234178.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X15
XM_054378211.1 → XP_054234186.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X23
XM_054378210.1 → XP_054234185.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X22
XM_054378206.1 → XP_054234181.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X18
XM_054378208.1 → XP_054234183.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X20
XM_054378204.1 → XP_054234179.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X16
XM_054378202.1 → XP_054234177.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X14
XM_054378201.1 → XP_054234176.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X13
XM_054378199.1 → XP_054234174.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X11
XM_054378196.1 → XP_054234171.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X8
XM_054378191.1 → XP_054234166.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3
XM_054378200.1 → XP_054234175.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X12
XM_054378197.1 → XP_054234172.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X9
XM_054378194.1 → XP_054234169.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X6
XM_054378193.1 → XP_054234168.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5
XM_054378198.1 → XP_054234173.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X10
XM_054378195.1 → XP_054234170.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7
XM_054378190.1 → XP_054234165.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2
XM_054378192.1 → XP_054234167.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4
XM_054378189.1 → XP_054234164.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
XM_054378212.1 → XP_054234187.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X24

UniProtKB/TrEMBL

Q59F77
XM_054378213.1 → XP_054234188.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X25

UniProtKB/TrEMBL

Q59F77
XM_054378214.1 → XP_054234189.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X26