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    MPPE1 metallophosphoesterase 1 [ Homo sapiens (human) ]

    Gene ID: 65258, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MPPE1provided by HGNC
    Official Full Name
    metallophosphoesterase 1provided by HGNC
    Primary source
    HGNC:HGNC:15988
    See related
    Ensembl:ENSG00000154889 MIM:611900; AllianceGenome:HGNC:15988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cdc1; PGAP5
    Summary
    Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Involved in GPI anchor biosynthetic process. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.2), prostate (RPKM 8.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MPPE1 in Genome Data Viewer
    Location:
    18p11.21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (11882622..11908317, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (12045331..12071022, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (11882621..11908316, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha L Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:11856862-11858061 Neighboring gene uncharacterized LOC124904251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:11861344-11862250 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:11875590-11875801 Neighboring gene uncharacterized LOC124904252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9301 Neighboring gene uncharacterized LOC101927511 Neighboring gene CRISPRi-validated cis-regulatory element chr18.397 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:11951641-11952330 Neighboring gene Sharpr-MPRA regulatory region 7933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13098 Neighboring gene inositol monophosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence. Chen X, et al. Cancer Biol Ther, 2020 Nov 1. PMID 33054568, Free PMC Article
    2. cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2. Vuoristo JT, et al. Cytogenet Cell Genet, 2001. PMID 11978971
    3. Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder. Lohoff FW, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Apr 5. PMID 19859903, Free PMC Article
    4. GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. Fujita M, et al. Cell, 2009 Oct 16. PMID 19837036
    5. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Hirata T, et al. Nat Commun, 2018 Jan 26. PMID 29374258, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence.
      Title: Metallophosphoesterase 1, a novel candidate gene in hepatocellular carcinoma malignancy and recurrence.
    2. These results provide evidence of an association between a polymorphism in the MPPE1 gene and bipolar disorder.
      Title: Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.
    3. Data demonstrate that glycosylphosphatidylinositol(GPI) glycan acts as an endoplasmic reticulum-exit signal and suggest that glycan remodeling mediated by PGAP5 regulates GPI-anchored proteins transport in the early secretory pathway.
      Title: GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.
    5. cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2
      Title: cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GPI anchor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GPI-mannose ethanolamine phosphate phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cis-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    metallophosphoesterase 1
    Names
    metallo phosphoesterase
    post-GPI attachment to proteins 5
    post-GPI attachment to proteins factor 5
    NP_001229833.1
    NP_001306083.1
    NP_001317492.1
    NP_075563.3
    XP_006722403.1
    XP_006722404.1
    XP_006722405.1
    XP_006722406.1
    XP_006722408.1
    XP_006722409.1
    XP_006722411.1
    XP_011524033.1
    XP_011524034.1
    XP_016881411.1
    XP_016881412.1
    XP_016881413.1
    XP_016881414.1
    XP_016881416.1
    XP_016881417.1
    XP_016881418.1
    XP_016881419.1
    XP_016881420.1
    XP_047293699.1
    XP_047293700.1
    XP_047293701.1
    XP_047293702.1
    XP_047293703.1
    XP_047293704.1
    XP_047293705.1
    XP_047293706.1
    XP_047293707.1
    XP_047293708.1
    XP_047293709.1
    XP_047293710.1
    XP_047293711.1
    XP_047293712.1
    XP_054174962.1
    XP_054174963.1
    XP_054174964.1
    XP_054174965.1
    XP_054174966.1
    XP_054174967.1
    XP_054174968.1
    XP_054174969.1
    XP_054174970.1
    XP_054174971.1
    XP_054174972.1
    XP_054174973.1
    XP_054174974.1
    XP_054174975.1
    XP_054174976.1
    XP_054174977.1
    XP_054174978.1
    XP_054174979.1
    XP_054174980.1
    XP_054174981.1
    XP_054174982.1
    XP_054174983.1
    XP_054174984.1
    XP_054174985.1
    XP_054174986.1
    XP_054174987.1
    XP_054174988.1
    XP_054174989.1
    XP_054174990.1
    XP_054174991.1
    XP_054174992.1
    XP_054174993.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242904.2 → NP_001229833.1  metallophosphoesterase 1 isoform 2

      See identical proteins and their annotated locations for NP_001229833.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5'UTR and lacks two consecutive exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Both variants 2 and 6 encode the same isoform.
      Source sequence(s)
      AL833636, AP001269, AW663162, BC002877, CR738004, DB035278
      Consensus CDS
      CCDS56054.1
      UniProtKB/Swiss-Prot
      Q53F39
      Related
      ENSP00000311200.9, ENST00000309976.13
      Conserved Domains (1) summary
      cd08165
      Location:73 → 266
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    2. NM_001319154.2 → NP_001306083.1  metallophosphoesterase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two consecutive exons in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Both variants 2 and 6 encode the same isoform.
      Source sequence(s)
      AL536593, AL833636, AP001269
      Consensus CDS
      CCDS56054.1
      UniProtKB/Swiss-Prot
      Q53F39
      Related
      ENSP00000327257.6, ENST00000317235.11
      Conserved Domains (1) summary
      cd08165
      Location:73 → 266
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    3. NM_001330563.2 → NP_001317492.1  metallophosphoesterase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL833636, AP001269
      Consensus CDS
      CCDS82242.1
      UniProtKB/TrEMBL
      A0A0A0MR93
      Related
      ENSP00000339423.7, ENST00000344987.11
      Conserved Domains (2) summary
      cd08165
      Location:73 → 307
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 283
      Metallophos; Calcineurin-like phosphoesterase

    4. NM_023075.6 → NP_075563.3  metallophosphoesterase 1 isoform 1

      See identical proteins and their annotated locations for NP_075563.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF363484, AL833636, AP001269, AW663162, BC002877, DB035278
      Consensus CDS
      CCDS11853.1
      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4
      Related
      ENSP00000465894.1, ENST00000588072.6
      Conserved Domains (2) summary
      cd08165
      Location:73 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 305
      Metallophos; Calcineurin-like phosphoesterase

    RNA

    1. NR_040241.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate penultimate exon. This results in a frameshift and premature stop codon which renders the transcript a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      AF289560, AL833636, AP001269, AW663162, BC073994

    2. NR_040242.4 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes 2 alternate exons and represents use of an alternate splice acceptor site, compared to variant 1. These differences result in a frameshift and premature stop codon which renders the transcript a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      AK021647, AK054639, AL833636, AP001269, AW663162, BC073994, DB035278

    3. NR_040243.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate penultimate exon compared to variant 1. This results in a frameshift and premature stop codon which renders the transcript a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      AL833636, AP001269, AW663162, BC002877, BC073994, CR738004, DB035278

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      11882622..11908317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025929.3 → XP_016881418.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93
      Conserved Domains (2) summary
      cd08165
      Location:73 → 307
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 283
      Metallophos; Calcineurin-like phosphoesterase

    2. XM_006722346.4 → XP_006722409.1  metallophosphoesterase 1 isoform X2

      See identical proteins and their annotated locations for XP_006722409.1

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4
      Conserved Domains (2) summary
      cd08165
      Location:73 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 305
      Metallophos; Calcineurin-like phosphoesterase

    3. XM_006722345.5 → XP_006722408.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_006722408.1

      Conserved Domains (2) summary
      cd08165
      Location:73 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 306
      Metallophos; Calcineurin-like phosphoesterase

    4. XM_006722340.4 → XP_006722403.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_006722403.1

      Conserved Domains (2) summary
      cd08165
      Location:73 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 306
      Metallophos; Calcineurin-like phosphoesterase

    5. XM_017025927.3 → XP_016881416.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93
      Conserved Domains (2) summary
      cd08165
      Location:73 → 307
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 283
      Metallophos; Calcineurin-like phosphoesterase

    6. XM_017025924.3 → XP_016881413.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4
      Conserved Domains (2) summary
      cd08165
      Location:73 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 305
      Metallophos; Calcineurin-like phosphoesterase

    7. XM_006722342.5 → XP_006722405.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_006722405.1

      Conserved Domains (2) summary
      cd08165
      Location:73 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 306
      Metallophos; Calcineurin-like phosphoesterase

    8. XM_017025928.2 → XP_016881417.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93
      Conserved Domains (2) summary
      cd08165
      Location:73 → 307
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 283
      Metallophos; Calcineurin-like phosphoesterase

    9. XM_017025925.2 → XP_016881414.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4
      Conserved Domains (2) summary
      cd08165
      Location:73 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 305
      Metallophos; Calcineurin-like phosphoesterase

    10. XM_006722343.4 → XP_006722406.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_006722406.1

      Conserved Domains (2) summary
      cd08165
      Location:73 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 306
      Metallophos; Calcineurin-like phosphoesterase

    11. XM_047437753.1 → XP_047293709.1  metallophosphoesterase 1 isoform X6

    12. XM_047437748.1 → XP_047293704.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93

    13. XM_017025922.3 → XP_016881411.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4
      Conserved Domains (2) summary
      cd08165
      Location:73 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 305
      Metallophos; Calcineurin-like phosphoesterase

    14. XM_006722341.5 → XP_006722404.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_006722404.1

      Conserved Domains (2) summary
      cd08165
      Location:73 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 306
      Metallophos; Calcineurin-like phosphoesterase

    15. XM_047437746.1 → XP_047293702.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    16. XM_047437745.1 → XP_047293701.1  metallophosphoesterase 1 isoform X1

    17. XM_047437754.1 → XP_047293710.1  metallophosphoesterase 1 isoform X6

    18. XM_017025923.3 → XP_016881412.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4
      Conserved Domains (2) summary
      cd08165
      Location:73 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 305
      Metallophos; Calcineurin-like phosphoesterase

    19. XM_011525731.4 → XP_011524033.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_011524033.1

      Conserved Domains (2) summary
      cd08165
      Location:73 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 306
      Metallophos; Calcineurin-like phosphoesterase

    20. XM_047437744.1 → XP_047293700.1  metallophosphoesterase 1 isoform X1

    21. XM_047437749.1 → XP_047293705.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93

    22. XM_047437747.1 → XP_047293703.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    23. XM_047437743.1 → XP_047293699.1  metallophosphoesterase 1 isoform X1

    24. XM_017025930.3 → XP_016881419.1  metallophosphoesterase 1 isoform X5

      UniProtKB/TrEMBL
      K7ES91
      Related
      ENSP00000468606.1, ENST00000592977.5
      Conserved Domains (2) summary
      cd08165
      Location:73 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 305
      Metallophos; Calcineurin-like phosphoesterase

    25. XM_047437750.1 → XP_047293706.1  metallophosphoesterase 1 isoform X5

      UniProtKB/TrEMBL
      K7ES91
      Related
      ENSP00000433950.1, ENST00000496196.5

    26. XM_011525732.3 → XP_011524034.1  metallophosphoesterase 1 isoform X4

      UniProtKB/TrEMBL
      K7ES91
      Conserved Domains (2) summary
      cd08165
      Location:73 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 306
      Metallophos; Calcineurin-like phosphoesterase

    27. XM_047437752.1 → XP_047293708.1  metallophosphoesterase 1 isoform X5

      UniProtKB/TrEMBL
      K7ES91

    28. XM_047437756.1 → XP_047293712.1  metallophosphoesterase 1 isoform X10

    29. XM_047437755.1 → XP_047293711.1  metallophosphoesterase 1 isoform X7

      UniProtKB/TrEMBL
      K7ES91

    30. XM_047437751.1 → XP_047293707.1  metallophosphoesterase 1 isoform X5

      UniProtKB/TrEMBL
      K7ES91

    31. XM_006722348.3 → XP_006722411.1  metallophosphoesterase 1 isoform X9

      UniProtKB/TrEMBL
      K7ES91
      Conserved Domains (2) summary
      cd08165
      Location:73 → 178
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:70 → 194
      Metallophos; Calcineurin-like phosphoesterase

    32. XM_017025931.2 → XP_016881420.1  metallophosphoesterase 1 isoform X8

      UniProtKB/TrEMBL
      K7ES91
      Related
      ENST00000589731.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      12045331..12071022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319007.1 → XP_054174982.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93

    2. XM_054319002.1 → XP_054174977.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    3. XM_054318992.1 → XP_054174967.1  metallophosphoesterase 1 isoform X1

    4. XM_054318987.1 → XP_054174962.1  metallophosphoesterase 1 isoform X1

    5. XM_054319004.1 → XP_054174979.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93

    6. XM_054318997.1 → XP_054174972.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    7. XM_054318989.1 → XP_054174964.1  metallophosphoesterase 1 isoform X1

    8. XM_054319006.1 → XP_054174981.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93

    9. XM_054319001.1 → XP_054174976.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    10. XM_054318991.1 → XP_054174966.1  metallophosphoesterase 1 isoform X1

    11. XM_054319013.1 → XP_054174988.1  metallophosphoesterase 1 isoform X6

    12. XM_054319003.1 → XP_054174978.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93

    13. XM_054318996.1 → XP_054174971.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    14. XM_054318988.1 → XP_054174963.1  metallophosphoesterase 1 isoform X1

    15. XM_054318998.1 → XP_054174973.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    16. XM_054318995.1 → XP_054174970.1  metallophosphoesterase 1 isoform X1

    17. XM_054319014.1 → XP_054174989.1  metallophosphoesterase 1 isoform X6

    18. XM_054319000.1 → XP_054174975.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    19. XM_054318990.1 → XP_054174965.1  metallophosphoesterase 1 isoform X1

    20. XM_054318994.1 → XP_054174969.1  metallophosphoesterase 1 isoform X1

    21. XM_054319005.1 → XP_054174980.1  metallophosphoesterase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MR93

    22. XM_054318999.1 → XP_054174974.1  metallophosphoesterase 1 isoform X2

      UniProtKB/Swiss-Prot
      B0YJ39, B0YJ40, B0YJ41, B5ME53, B7WNJ3, D3DUI5, D3DUI7, Q53F39, Q6GMP1, Q8TAD6, Q8TE26, Q8WZ32, Q9BU58, Q9H958, Q9HAI4

    23. XM_054318993.1 → XP_054174968.1  metallophosphoesterase 1 isoform X1

    24. XM_054319012.1 → XP_054174987.1  metallophosphoesterase 1 isoform X5

      UniProtKB/TrEMBL
      K7ES91

    25. XM_054319009.1 → XP_054174984.1  metallophosphoesterase 1 isoform X5

      UniProtKB/TrEMBL
      K7ES91

    26. XM_054319008.1 → XP_054174983.1  metallophosphoesterase 1 isoform X4

      UniProtKB/TrEMBL
      K7ES91

    27. XM_054319011.1 → XP_054174986.1  metallophosphoesterase 1 isoform X5

      UniProtKB/TrEMBL
      K7ES91

    28. XM_054319018.1 → XP_054174993.1  metallophosphoesterase 1 isoform X10

    29. XM_054319015.1 → XP_054174990.1  metallophosphoesterase 1 isoform X7

      UniProtKB/TrEMBL
      K7ES91

    30. XM_054319010.1 → XP_054174985.1  metallophosphoesterase 1 isoform X5

      UniProtKB/TrEMBL
      K7ES91

    31. XM_054319017.1 → XP_054174992.1  metallophosphoesterase 1 isoform X9

      UniProtKB/TrEMBL
      K7ES91

    32. XM_054319016.1 → XP_054174991.1  metallophosphoesterase 1 isoform X8

      UniProtKB/TrEMBL
      K7ES91

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138608.2: Suppressed sequence

      Description
      NM_138608.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53F39.2 GenPept UniProtKB/Swiss-Prot:Q53F39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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