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    ADGRL4 adhesion G protein-coupled receptor L4 [ Homo sapiens (human) ]

    Gene ID: 64123, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ADGRL4provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor L4provided by HGNC
    Primary source
    HGNC:HGNC:20822
    See related
    Ensembl:ENSG00000162618 MIM:616419; AllianceGenome:HGNC:20822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ETL; ELTD1; KPG_003
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in fat (RPKM 38.7), spleen (RPKM 20.4) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRL4 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (78889764..79006730, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (78728626..78845196, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (79355449..79472415, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:79262697-79263301 Neighboring gene uncharacterized LOC124904203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1238 Neighboring gene VISTA enhancer hs1989 Neighboring gene phosphoserine aminotransferase 1 pseudogene 3 Neighboring gene uncharacterized LOC107984998 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:79603859-79604407

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression. Sheldon H, et al. Mol Cancer Res, 2021 Nov. PMID 34348993, Free PMC Article
    2. Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling. Favara DM, et al. Sci Rep, 2021 Apr 23. PMID 33893326, Free PMC Article
    3. Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion. Guihurt Santiago J, et al. BMC Cancer, 2021 Jan 11. PMID 33430814, Free PMC Article
    4. ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype. Sheldon H, et al. Int J Mol Sci, 2021 Oct 19. PMID 34681953, Free PMC Article
    5. A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Masiero M, et al. Cancer Cell, 2013 Aug 12. PMID 23871637, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.
      Title: ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression.
    2. ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
      Title: ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
    3. ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer.
      Title: ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer.
    4. ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype.
      Title: ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype.
    5. Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling.
      Title: Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling.
    6. Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion.
      Title: Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion.
    7. ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1alpha signaling axis.
      Title: ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1α signaling axis.
    8. High ELTD1 expression is associated with glioma.
      Title: ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models.
    9. miR-139-5p suppresses glioblastoma multiforme cell proliferation by targeting ELTD1 and regulating cell cycle.
      Title: MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme.
    10. Results provide insight into the regulation of tumor angiogenesis and highlight ELTD1 as key player in blood vessel formation.
      Title: A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L4
    Names
    EGF, latrophilin and seven transmembrane domain containing 1
    EGF, latrophilin and seven transmembrane domain-containing protein 1
    EGF-TM7-latrophilin-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022159.4 → NP_071442.2  adhesion G protein-coupled receptor L4 precursor

      See identical proteins and their annotated locations for NP_071442.2

      Status: VALIDATED

      Source sequence(s)
      AB032017, AC099674, AK129766, DA477962
      Consensus CDS
      CCDS41352.1
      UniProtKB/Swiss-Prot
      B1AR71, Q5KU34, Q9HBW9
      UniProtKB/TrEMBL
      A8KA29
      Related
      ENSP00000359778.3, ENST00000370742.4
      Conserved Domains (4) summary
      pfam01825
      Location:368 → 412
      GPS; GPCR proteolysis site, GPS, motif
      pfam07645
      Location:58 → 91
      EGF_CA; Calcium-binding EGF domain
      pfam16489
      Location:139 → 330
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl21561
      Location:424 → 660
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      78889764..79006730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      78728626..78845196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HBW9.3 GenPept UniProtKB/Swiss-Prot:Q9HBW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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