OR52A1 olfactory receptor family 52 subfamily A member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OR52A1provided by HGNC
Official Full Name: olfactory receptor family 52 subfamily A member 1provided by HGNC
Primary source: HGNC:HGNC:8318
See related: Ensembl:ENSG00000182070 AllianceGenome:HGNC:8318
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HPFH1OR
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs: all
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Genomic context

Location:: 11p15.4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (5146824..5154757, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (5206166..5214099, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (5168054..5175987, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Human variation in alcohol response is influenced by variation in neuronal signaling genes.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of olfactory receptor, family 52, subfamily A, member 1 (OR52A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Go to the HIV-1, Human Interaction Database

General gene information

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Markers

ECD03177 (e-PCR)
- UniSTS:284262

ECD01626 (e-PCR)
- UniSTS:282727

ECD03217 (e-PCR)
- UniSTS:284302

NoName (e-PCR)
- UniSTS:481720

REN97076 (e-PCR)
- UniSTS:421874

REN97077 (e-PCR)
- UniSTS:421875

REN97078 (e-PCR)
- UniSTS:421876

REN97079 (e-PCR)
- UniSTS:421877

REN97080 (e-PCR)
- UniSTS:421878

REN97081 (e-PCR)
- UniSTS:421879

REN97082 (e-PCR)
- UniSTS:421880

REN97083 (e-PCR)
- UniSTS:421881

REN97084 (e-PCR)
- UniSTS:421882

REN97085 (e-PCR)
- UniSTS:421883

REN97086 (e-PCR)
- UniSTS:421884

REN97087 (e-PCR)
- UniSTS:421885

REN97088 (e-PCR)
- UniSTS:421886

REN97089 (e-PCR)
- UniSTS:421887

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of smell	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: olfactory receptor 52A1

Names: odorant receptor HOR3'beta4; olfactory receptor OR11-319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027733.1 RefSeqGene

Range

5001..5939

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_012375.3 → NP_036507.2 olfactory receptor 52A1

See identical proteins and their annotated locations for NP_036507.2

Status: VALIDATED

Source sequence(s)

AC129505

Consensus CDS

CCDS31374.1

UniProtKB/Swiss-Prot

Q6IF31, Q9UKL2

UniProtKB/TrEMBL

A0A126GVH8

Related

ENSP00000369725.1, ENST00000380367.3

Conserved Domains (2) summary

pfam00001
Location:43 → 295

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:33 → 311

7tm_4; Olfactory receptor