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    NCK1-DT NCK1 divergent transcript [ Homo sapiens (human) ]

    Gene ID: 101927597, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NCK1-DTprovided by HGNC
    Official Full Name
    NCK1 divergent transcriptprovided by HGNC
    Primary source
    HGNC:HGNC:49645
    See related
    Ensembl:ENSG00000239213 AllianceGenome:HGNC:49645
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCK1-AS1; SLC35G2-AS1
    Expression
    Ubiquitous expression in lymph node (RPKM 2.8), spleen (RPKM 2.7) and 25 other tissues See more
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    Genomic context

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    See NCK1-DT in Genome Data Viewer
    Location:
    3q22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (136841976..136862063, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (139582626..139602716, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136560818..136580905, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr3:136470665-136471596 and GRCh37_chr3:136471597-136472528 Neighboring gene STAG1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14760 Neighboring gene sulfotransferase family 1D member 1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14761 Neighboring gene solute carrier family 35 member G2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136587915-136588414 Neighboring gene NCK adaptor protein 1 Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene MPRA-validated peak4840 silencer Neighboring gene IL20RB antisense RNA 1 Neighboring gene interleukin 20 receptor subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. A review on the role of NCK1 Antisense RNA 1 (NCK1-AS1) in diverse disorders. Taheri M, et al. Pathol Res Pract, 2023 May. PMID 37028107
    2. Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis. He XY, et al. Cell Cycle, 2023 Mar. PMID 36412985, Free PMC Article
    3. LncRNA NCK1-AS1-mediated regulatory functions in human diseases. Wang Y, et al. Clin Transl Oncol, 2023 Feb. PMID 36131072
    4. LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling. Zhou W, et al. J Gastrointestin Liver Dis, 2022 Mar 19. PMID 35306563
    5. LncRNA NCK1-AS1 promotes proliferation and induces cell cycle progression by crosstalk NCK1-AS1/miR-6857/CDK1 pathway. Li H, et al. Cell Death Dis, 2018 Feb 7. PMID 29416014, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis.
      Title: NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis.
    2. A review on the role of NCK1 Antisense RNA 1 (NCK1-AS1) in diverse disorders.
      Title: A review on the role of NCK1 Antisense RNA 1 (NCK1-AS1) in diverse disorders.
    3. Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis.
      Title: Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis.
    4. LncRNA NCK1-AS1-mediated regulatory functions in human diseases.
      Title: LncRNA NCK1-AS1-mediated regulatory functions in human diseases.
    5. LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling.
      Title: LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling.
    6. NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC.
      Title: NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC.
    7. Upregulation of lncRNA NCK1-AS1 predicts poor prognosis and contributes to non-small cell lung cancer proliferation by regulating CDK1.
      Title: Upregulation of lncRNA NCK1-AS1 predicts poor prognosis and contributes to non-small cell lung cancer proliferation by regulating CDK1.
    8. LncRNA NCK1-AS1 promotes non-small cell lung cancer progression via regulating miR-512-5p/p21 axis.
      Title: LncRNA NCK1-AS1 promotes non-small cell lung cancer progression via regulating miR-512-5p/p21 axis.
    9. NCK1-AS1 Increases Drug Resistance of Glioma Cells to Temozolomide by Modulating miR-137/TRIM24.
      Title: NCK1-AS1 Increases Drug Resistance of Glioma Cells to Temozolomide by Modulating miR-137/TRIM24.
    10. NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer.
      Title: NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Other Names

    • NCK1 antisense RNA 1 (head to head)
    • SLC35G2 antisense RNA 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110175.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AA708729, AC011597, HY007950
      Related
      ENST00000474250.6

    2. NR_110176.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an internal exon resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AA708729, AC011597, CB047433

    3. NR_110177.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AA708729, AC011597, DA714434, HY007950
      Related
      ENST00000762166.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      136841976..136862063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      139582626..139602716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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