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    HS6ST3 heparan sulfate 6-O-sulfotransferase 3 [ Homo sapiens (human) ]

    Gene ID: 266722, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HS6ST3provided by HGNC
    Official Full Name
    heparan sulfate 6-O-sulfotransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:19134
    See related
    Ensembl:ENSG00000185352 MIM:609401; AllianceGenome:HGNC:19134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HS6ST-3
    Summary
    Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in brain (RPKM 5.5), urinary bladder (RPKM 1.6) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HS6ST3 in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (96090107..96839562)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (95294349..96043658)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96742361..97491816)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5448 Neighboring gene Sharpr-MPRA regulatory region 4273 Neighboring gene MT-CYB pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96558977-96559478 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:96606253-96607155 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96611347-96611848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96611849-96612348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96666836-96667336 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:96693792-96694381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96705417-96705916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96741684-96742184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96742185-96742685 Neighboring gene RNA, 7SL, cytoplasmic 164, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:96947250-96948184 Neighboring gene microRNA 4501 Neighboring gene AMMECR1 like pseudogene 1 Neighboring gene MPRA-validated peak2102 silencer Neighboring gene uncharacterized LOC124903195 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:97469055-97469812 Neighboring gene Sharpr-MPRA regulatory region 11714 Neighboring gene heat shock protein 90 alpha family class B member 6, pseudogene Neighboring gene long intergenic non-protein coding RNA 359 Neighboring gene TUB like protein 3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1. Iravani O, et al. Exp Cell Res, 2017 Jan 15. PMID 28017727
    2. Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction. Wang KS, et al. J Genet, 2013 Dec. PMID 24371161
    3. The heparan and heparin metabolism pathway is involved in regulation of fatty acid composition. Jiang Z, et al. Int J Biol Sci, 2011. PMID 21647334, Free PMC Article
    4. Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity. Nagai N, et al. J Cell Sci, 2004 Jul 1. PMID 15226404
    5. Genome-wide association study of diabetic retinopathy in a Taiwanese population. Huang YC, et al. Ophthalmology, 2011 Apr. PMID 21310492

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing HS6ST3 diminished tumor cell growth and progression in breast cancer cells. Silencing HS6ST3 down-regulated IGF1R and up-regulated XAF1.
      Title: Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1.
    2. Single-nucleotide polymorphisms within the HS6ST3 gene are associated with obesity and triglyceride levels. [Meta-analysis]
      Title: Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene x gender interaction.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of diabetic retinopathy in a Taiwanese population.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp761K2315

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heparan sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparan-sulfate 6-O-sulfotransferase 3
    NP_703157.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153456.4 → NP_703157.2  heparan-sulfate 6-O-sulfotransferase 3

      Status: VALIDATED

      Source sequence(s)
      AL138816, AL158192, AL353581
      Consensus CDS
      CCDS9481.1
      UniProtKB/Swiss-Prot
      Q5W0L0, Q68CW6, Q8IZP7
      Related
      ENSP00000365895.2, ENST00000376705.4
      Conserved Domains (1) summary
      pfam03567
      Location:144 → 410
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      96090107..96839562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      95294349..96043658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZP7.3 GenPept UniProtKB/Swiss-Prot:Q8IZP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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