ZNF296 zinc finger protein 296 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF296provided by HGNC
Official Full Name: zinc finger protein 296provided by HGNC
Primary source: HGNC:HGNC:15981
See related: Ensembl:ENSG00000170684 MIM:613226; AllianceGenome:HGNC:15981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZFP296; ZNF342
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of dendrite development; regulation of transcription by RNA polymerase II; and spermatogenesis. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bone marrow (RPKM 1.9), spleen (RPKM 1.8) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (45071500..45076478, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (47896615..47901608, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (45574758..45579736, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

novel translocation t(17;19)(q22;q13.32)in acute myeloid leukemia mapping to 352 bp 5 of MPO on 17q & 2,085 bp 5 of ZNF342 on 19q on derivative chromosome 17; higher level of ZNF342 expression in acute lymphoblastic leukemia associated with poorer outcome
Title: Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t(17;19)(q23;q13.32) in pediatric acute myeloid leukemia and analysis of ZNF342 expression in leukemia.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 296

Names: zinc finger protein 342

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145288.3 → NP_660331.1 zinc finger protein 296

See identical proteins and their annotated locations for NP_660331.1

Status: VALIDATED

Source sequence(s)

BC019352, BF434185

Consensus CDS

CCDS12653.1

UniProtKB/Swiss-Prot

Q8WUU4

UniProtKB/TrEMBL

Q8IX33

Related

ENSP00000302770.1, ENST00000303809.7

Conserved Domains (5) summary

sd00017
Location:388 → 408

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:233 → 253

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:387 → 408

zf-C2H2; Zinc finger, C2H2 type

pfam12756
Location:387 → 467

zf-C2H2_2; C2H2 type zinc-finger (2 copies)

pfam13465
Location:245 → 270

zf-H2C2_2; Zinc-finger double domain