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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029124.2 RefSeqGene
- Range
-
4987..14623
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001223.5 → NP_001214.1 caspase-1 isoform beta precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (beta) lacks an in-frame exon in the coding region, compared to variant alpha. Variant beta encodes a protein lacking an internal segment, compared to isoform alpha.Variant beta and variant 7 encode the same protein.
- Source sequence(s)
-
AA505065, AP001153, KF455483, U13697
- Consensus CDS
-
CCDS8329.1
- UniProtKB/TrEMBL
-
A8K257
- Related
- ENSP00000512117.1, ENST00000695719.1
- Conserved Domains (2) summary
-
- smart00115
Location:132 → 381
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
- cd08325
Location:5 → 87
- CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
-
NM_001257118.3 → NP_001244047.1 caspase-1 isoform alpha precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) differs in the 3' UTR compared to variant alpha. Variant alpha and variant 6 encode the same protein.
- Source sequence(s)
-
AA737419, AK290114, AP001153, KF455483
- Consensus CDS
-
CCDS8330.1
- UniProtKB/Swiss-Prot
- B5MDZ1, P29466, Q53EY6, Q6DMQ1, Q6GSS3, Q6PI75, Q9UCN3
- UniProtKB/TrEMBL
- A8K249, B2R8U9
- Related
- ENSP00000433138.1, ENST00000533400.6
- Conserved Domains (2) summary
-
- smart00115
Location:153 → 402
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
- cd08325
Location:5 → 87
- CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
-
NM_001257119.3 → NP_001244048.1 caspase-1 isoform beta precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) lacks an alternate in-frame exon and differs in the 3' UTR compared to variant alpha. Variant beta and variant 7 encode the same protein.
- Source sequence(s)
-
AA737419, AK290122, AP001153, KF455483
- Consensus CDS
-
CCDS8329.1
- UniProtKB/TrEMBL
-
A8K257
- Related
- ENSP00000434779.1, ENST00000525825.6
- Conserved Domains (2) summary
-
- smart00115
Location:132 → 381
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
- cd08325
Location:5 → 87
- CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
-
NM_033292.4 → NP_150634.1 caspase-1 isoform alpha precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (alpha) encodes the longest isoform (alpha). Variant alpha and variant 6 encode the same protein.
- Source sequence(s)
-
AA505065, AP001153, KF455483, M87507
- Consensus CDS
-
CCDS8330.1
- UniProtKB/Swiss-Prot
- B5MDZ1, P29466, Q53EY6, Q6DMQ1, Q6GSS3, Q6PI75, Q9UCN3
- UniProtKB/TrEMBL
- A8K249, B2R8U9
- Related
- ENSP00000410076.3, ENST00000436863.7
- Conserved Domains (2) summary
-
- smart00115
Location:153 → 402
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
- cd08325
Location:5 → 87
- CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
-
NM_033293.4 → NP_150635.1 caspase-1 isoform gamma
Status: REVIEWED
- Description
- Transcript Variant: This variant (gamma) has multiple differences in the coding region but the translation remains in frame, compared to variant alpha. Variant gamma encodes a protein lacking an internal segment, as compared to isoform alpha.
- Source sequence(s)
-
AA761907, AP001153, KF455483, U13698
- Consensus CDS
-
CCDS53704.1
- UniProtKB/TrEMBL
-
A8K257
- Related
- ENSP00000434250.1, ENST00000526568.5
- Conserved Domains (1) summary
-
- smart00115
Location:60 → 309
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
-
NM_033294.4 → NP_150636.1 caspase-1 isoform delta
Status: REVIEWED
- Description
- Transcript Variant: This variant (delta) has multiple differences in the coding region but the translation remains in frame, compared to variant alpha. Variant delta encodes a protein lacking two internal segments, compared to the isoform alpha. Isoform delta lacks apoptosis-inducing activity.
- Source sequence(s)
-
AA761907, AP001153, KF455483, U13699
- Consensus CDS
-
CCDS8331.1
- UniProtKB/Swiss-Prot
-
P29466
- Related
- ENSP00000436875.1, ENST00000534497.5
- Conserved Domains (1) summary
-
- smart00115
Location:60 → 261
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
-
NM_033295.4 → NP_150637.1 caspase-1 isoform epsilon
Status: REVIEWED
- Description
- Transcript Variant: This variant (epsilon) has multiple differences in the coding region but the translation remains in frame, compared to variant alpha. Variant epsilon encodes a protein lacking an internal segment, compared to isoform alpha. Isoform epsilon lacks apoptosis-inducing activity.
- Source sequence(s)
-
AA761907, AP001153, KF455483, U13700
- Consensus CDS
-
CCDS8332.1
- UniProtKB/Swiss-Prot
-
P29466
- Related
- ENSP00000434303.1, ENST00000531166.5
- Conserved Domains (1) summary
-
- cl00042
Location:13 → 86
- CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...