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    CG2145 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32027, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG2145provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030251
    Locus tag
    Dmel_CG2145
    See related
    AllianceGenome:FB:FBgn0030251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2145; Dmel_CG2145
    Summary
    Enables RNA endonuclease activity. Involved in mRNA destabilization; negative regulation of lipid catabolic process; and post-transcriptional gene silencing. Is active in endoplasmic reticulum. Is expressed in adult head. Orthologous to human ENDOU (endonuclease, poly(U) specific). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2145 in Genome Data Viewer
    Location:
    9F11-9F12; 1-33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10927399..10929712)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10821432..10823745)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene vermilion Neighboring gene Myosin 10A Neighboring gene Rab at 9Fa Neighboring gene Rab at 9Fb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration. Laneve P, et al. Sci Rep, 2017 Jan 31. PMID 28139767, Free PMC Article
    2. Proteomics of protein trafficking by in vivo tissue-specific labeling. Droujinine IA, et al. Nat Commun, 2021 Apr 22. PMID 33888706, Free PMC Article
    3. The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging. Sun X, et al. Nat Commun, 2023 Oct 6. PMID 37803019, Free PMC Article
    4. Silencing of Euchromatic Transposable Elements as a Consequence of Nuclear Lamina Dysfunction. Cavaliere V, et al. Cells, 2020 Mar 5. PMID 32151001, Free PMC Article
    5. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2145-PA
    CG2145-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10927399..10929712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132440.2 → NP_572668.1  uncharacterized protein Dmel_CG2145, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNF0, Q8SY54, Q9VZ49, X2JJD6
      Related
      FBpp0073243, FBtr0073387
      Conserved Domains (1) summary
      pfam09412
      Location:330 → 590
      XendoU; Endoribonuclease XendoU

    2. NM_001298173.1 → NP_001285102.1  uncharacterized protein Dmel_CG2145, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285102.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNF0, Q8SY54, Q9VZ49, X2JJD6
      Conserved Domains (1) summary
      pfam09412
      Location:330 → 590
      XendoU; Endoribonuclease XendoU
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZ49.1 Q9VZ49
    X2JJD6 X2JJD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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