ALD2 aldehyde dehydrogenase (NAD(+)) ALD2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ALD2
Official Full Name: aldehyde dehydrogenase (NAD(+)) ALD2
Primary source: SGD:S000004780
Locus tag: YMR170C
See related: AllianceGenome:SGD:S000004780; FungiDB:YMR170C; VEuPathDB:YMR170C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables aldehyde dehydrogenase (NAD+) activity. Involved in beta-alanine biosynthetic process and polyamine catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH1A1 (aldehyde dehydrogenase 1 family member A1); ALDH1A2 (aldehyde dehydrogenase 1 family member A2); and ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ALD2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (601562..603082, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
Title: Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-aminopropanal dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables aldehyde dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in beta-alanine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pantothenate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in polyamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyamine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aldehyde dehydrogenase (NAD(+)) ALD2

NP_013893.1

EC 1.2.1.3

Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

601562..603082 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182674.1 → NP_013893.1 TPA: aldehyde dehydrogenase (NAD(+)) ALD2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013893.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZZ2, P47771

UniProtKB/TrEMBL

C8ZF30

Conserved Domains (1) summary

cd07144
Location:14 → 502

ALDH_ALD2-YMR170C; Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c)-like