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    Rsph4a Radial spoke head protein 4a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rsph4aprovided by FlyBase
    Official Full Name
    Radial spoke head protein 4aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034957
    Locus tag
    Dmel_CG3121
    See related
    AllianceGenome:FB:FBgn0034957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.109; CG3121; Dmel\CG3121; dRSPH4a
    Summary
    Involved in axoneme assembly. Predicted to be part of radial spoke. Predicted to be active in axoneme. Is expressed in adult head; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 11. Orthologous to human RSPH6A (radial spoke head 6 homolog A) and RSPH4A (radial spoke head component 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rsph4a in Genome Data Viewer
    Location:
    60B3-60B3; 2-106 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24017421..24019896)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19904944..19907419)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Obscurin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Xyloside xylosyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila. Wang Y, et al. J Genet Genomics, 2019 Jun 20. PMID 31281031
    2. Candidate transcriptomic sources of inbreeding depression in Drosophila melanogaster. Garcia C, et al. PLoS One, 2013. PMID 23922905, Free PMC Article
    3. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
    4. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article
    5. Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm. Ramesh R, et al. Antioxid Redox Signal, 2023 Jun. PMID 36509450, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement involved in cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of radial spoke IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    radial spoke head protein 4a
    Names
    CG3121-PA
    Rsph4a-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24017421..24019896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138025.3 → NP_611869.1  radial spoke head protein 4a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1D3
      Related
      FBpp0072070
      Conserved Domains (1) summary
      pfam04712
      Location:83 → 679
      Radial_spoke; Radial spokehead-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1D3 Q9W1D3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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