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    Pomp proteasome maturation protein [ Mus musculus (house mouse) ]

    Gene ID: 66537, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pompprovided by MGI
    Official Full Name
    proteasome maturation proteinprovided by MGI
    Primary source
    MGI:MGI:1913787
    See related
    Ensembl:ENSMUSG00000029649 AllianceGenome:MGI:1913787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ump1; 2510048O06Rik
    Summary
    Predicted to be involved in proteasome assembly. Located in cytoplasm and nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and thymus primordium. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 2. Orthologous to human POMP (proteasome maturation protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 79.0), CNS E11.5 (RPKM 73.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pomp in Genome Data Viewer
    Location:
    5 G3; 5 87.52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147797438..147812594)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147860628..147875784)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14882 Neighboring gene predicted gene, 35592 Neighboring gene predicted gene, 54314 Neighboring gene STARR-seq mESC enhancer starr_14883 Neighboring gene predicted gene, 35648 Neighboring gene solute carrier family 46, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E534 Neighboring gene predicted gene, 46943

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in proteasome assembly  
    involved_in proteasome assembly  
    involved_in proteasome assembly  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in membrane  
    located_in nuclear speck  
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    proteasome maturation protein
    Names
    proteassemblin
    protein UMP1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025624.3NP_079900.1  proteasome maturation protein

      See identical proteins and their annotated locations for NP_079900.1

      Status: VALIDATED

      Source sequence(s)
      AK011115, AK012455
      Consensus CDS
      CCDS39402.1
      UniProtKB/Swiss-Prot
      Q9CQT5, Q9CXV8, Q9CZL7
      Related
      ENSMUSP00000031654.7, ENSMUST00000031654.10
      Conserved Domains (1) summary
      pfam05348
      Location:25138
      UMP1; Proteasome maturation factor UMP1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      147797438..147812594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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