Ackr3 atypical chemokine receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ackr3provided by MGI
Official Full Name: atypical chemokine receptor 3provided by MGI
Primary source: MGI:MGI:109562
See related: Ensembl:ENSMUSG00000044337 AllianceGenome:MGI:109562
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1
Summary: Predicted to enable chemokine binding activity; chemokine receptor activity; and scavenger receptor activity. Involved in oculomotor nerve development. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in several cellular components, including cell surface; clathrin-coated pit; and endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human ACKR3 (atypical chemokine receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 169.3), heart adult (RPKM 116.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 45.28 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (90131702..90143446)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (90203980..90215724)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve.
Title: Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve.
ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa.
Title: ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa.
Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.
Title: Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.
CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting beta-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells.
Title: CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells.
Umbilical cord mesenchymal stem cells overexpressing CXCR7 facilitate treatment of ARDS-associated pulmonary fibrosis via inhibition of Notch/Jag1 mediated by the Wnt/beta-catenin pathway.
Title: Umbilical cord mesenchymal stem cells overexpressing CXCR7 facilitate treatment of ARDS-associated pulmonary fibrosis via inhibition of Notch/Jag1 mediated by the Wnt/β-catenin pathway.
An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.
Title: An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.
Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting beta-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis.
Title: Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis.
Histone deacetylase 2 regulates STAT1-dependent upregulation of atypical chemokine receptor 3 to induce M2 macrophage migration and immune escape in hepatocellular carcinoma.
Title: Histone deacetylase 2 regulates STAT1-dependent upregulation of atypical chemokine receptor 3 to induce M2 macrophage migration and immune escape in hepatocellular carcinoma.
CXCR4 and CXCR7 signaling promotes tumor progression and obesity-associated epithelial-mesenchymal transition in prostate cancer cells.
Title: CXCR4 and CXCR7 signaling promotes tumor progression and obesity-associated epithelial-mesenchymal transition in prostate cancer cells.
Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium.
Title: Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (19) 1 citation

General gene information

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Markers

AW541270 (e-PCR)
- UniSTS:178433

Cmkor1 (e-PCR), detects polymorphism
- UniSTS:141360

AF000236 (e-PCR)
- UniSTS:158826

27.MMHAP97FLA6.seq (e-PCR)
- UniSTS:123807

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-X-C chemokine binding	ISS Inferred from Sequence or Structural Similarity more info
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables C-X-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in oculomotor nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oculomotor nerve development	ISO Inferred from Sequence Orthology more info
involved_in oculomotor nerve development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mesenchymal stem cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal stem cell migration	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: atypical chemokine receptor 3

Names: C-X-C chemokine receptor type 7; G-protein coupled receptor RDC1 homolog; chemokine (C-X-C motif) receptor 7; chemokine orphan receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271607.1 → NP_001258536.1 atypical chemokine receptor 3

See identical proteins and their annotated locations for NP_001258536.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC110261, AC120878

Consensus CDS

CCDS15152.1

UniProtKB/Swiss-Prot

P56485, Q91WI0

Conserved Domains (1) summary

cd14987
Location:45 → 326

7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_007722.4 → NP_031748.2 atypical chemokine receptor 3

See identical proteins and their annotated locations for NP_031748.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC110261, AK031100, BQ033958

Consensus CDS

CCDS15152.1

UniProtKB/Swiss-Prot

P56485, Q91WI0

Related

ENSMUSP00000069114.5, ENSMUST00000065587.5

Conserved Domains (1) summary

cd14987
Location:45 → 326

7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

90131702..90143446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157069.1 → XP_036012962.1 atypical chemokine receptor 3 isoform X1

UniProtKB/Swiss-Prot

P56485, Q91WI0

Conserved Domains (1) summary

cd14987
Location:45 → 326

7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors