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    Cd22 CD22 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12483, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd22provided by MGI
    Official Full Name
    CD22 antigenprovided by MGI
    Primary source
    MGI:MGI:88322
    See related
    Ensembl:ENSMUSG00000030577 AllianceGenome:MGI:88322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lyb8; Lyb-8; A530093D23
    Summary
    Enables CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 81.5), mammary gland adult (RPKM 20.6) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cd22 in Genome Data Viewer
    Location:
    7 B1; 7 19.26 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30564829..30579767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30865404..30880342, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene free fatty acid receptor 3 Neighboring gene free fatty acid receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6534 Neighboring gene DNA segment, Chr 7, ERATO Doi 128, expressed Neighboring gene STARR-positive B cell enhancer ABC_E1732 Neighboring gene myelin-associated glycoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CD4 receptor binding  
    enables CD4 receptor binding PubMed 
    enables carbohydrate binding  
    enables coreceptor activity PubMed 
    enables protein binding PubMed 
    enables protein phosphatase binding  
    enables protein phosphatase binding PubMed 
    enables sialic acid binding  
    enables sialic acid binding PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation  
    involved_in B cell activation  
    involved_in B cell activation  
    involved_in cell adhesion  
    acts_upstream_of_or_within cell surface receptor signaling pathway PubMed 
    involved_in negative regulation of B cell receptor signaling pathway  
    involved_in negative regulation of B cell receptor signaling pathway  
    involved_in negative regulation of B cell receptor signaling pathway  
    involved_in negative regulation of calcium-mediated signaling PubMed 
    involved_in negative regulation of immunoglobulin production PubMed 
    involved_in regulation of B cell proliferation  
    involved_in regulation of B cell proliferation PubMed 
    involved_in regulation of endocytosis  
    involved_in regulation of endocytosis  
    involved_in regulation of immune response PubMed 
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    is_active_in early endosome  
    located_in early endosome  
    located_in early endosome  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane PubMed 
    located_in neuronal cell body membrane PubMed 
    located_in plasma membrane PubMed 
    is_active_in recycling endosome  
    located_in recycling endosome  
    located_in recycling endosome  

    General protein information

    Preferred Names
    B-cell receptor CD22
    Names
    B-lymphocyte cell adhesion molecule
    BL-CAM
    T-cell surface antigen Leu-14
    sialic acid-binding Ig-like lectin 2
    siglec-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043317.2NP_001036782.1  B-cell receptor CD22 precursor

      See identical proteins and their annotated locations for NP_001036782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer protein-coding transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC165340, AK143835
      Consensus CDS
      CCDS21114.1
      UniProtKB/Swiss-Prot
      P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51
      UniProtKB/TrEMBL
      Q3TAX0
      Related
      ENSMUSP00000139871.2, ENSMUST00000190617.7
      Conserved Domains (3) summary
      smart00408
      Location:366424
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:260334
      Ig_3; Immunoglobulin domain
      cl11960
      Location:153239
      Ig; Immunoglobulin domain
    2. NM_009845.3NP_033975.3  B-cell receptor CD22 precursor

      See identical proteins and their annotated locations for NP_033975.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC165340, AK143835
      Consensus CDS
      CCDS21114.1
      UniProtKB/Swiss-Prot
      P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51
      UniProtKB/TrEMBL
      Q3TAX0
      Related
      ENSMUSP00000019248.7, ENSMUST00000019248.13
      Conserved Domains (3) summary
      smart00408
      Location:366424
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:260334
      Ig_3; Immunoglobulin domain
      cl11960
      Location:153239
      Ig; Immunoglobulin domain

    RNA

    1. NR_102722.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and uses an alternate splice junction at the 5' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC165340, AK041230
    2. NR_102723.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC165340, BC046957

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30564829..30579767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539493.1XP_006539556.1  B-cell receptor CD22 isoform X2

      See identical proteins and their annotated locations for XP_006539556.1

      UniProtKB/Swiss-Prot
      P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51
      UniProtKB/TrEMBL
      Q3TAX0
      Related
      ENSMUSP00000139685.2, ENSMUST00000186154.7
      Conserved Domains (3) summary
      smart00408
      Location:366424
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:260334
      Ig_3; Immunoglobulin domain
      cl11960
      Location:153239
      Ig; Immunoglobulin domain
    2. XM_006539490.1XP_006539553.1  B-cell receptor CD22 isoform X1

      See identical proteins and their annotated locations for XP_006539553.1

      UniProtKB/TrEMBL
      Q3TAX0
      Conserved Domains (3) summary
      smart00408
      Location:377435
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:271345
      Ig_3; Immunoglobulin domain
      cl11960
      Location:164250
      Ig; Immunoglobulin domain
    3. XM_006539491.3XP_006539554.1  B-cell receptor CD22 isoform X1

      See identical proteins and their annotated locations for XP_006539554.1

      UniProtKB/TrEMBL
      Q3TAX0
      Conserved Domains (3) summary
      smart00408
      Location:377435
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:271345
      Ig_3; Immunoglobulin domain
      cl11960
      Location:164250
      Ig; Immunoglobulin domain
    4. XM_006539489.4XP_006539552.1  B-cell receptor CD22 isoform X1

      See identical proteins and their annotated locations for XP_006539552.1

      UniProtKB/TrEMBL
      Q3TAX0
      Conserved Domains (3) summary
      smart00408
      Location:377435
      IGc2; Immunoglobulin C-2 Type
      pfam13927
      Location:271345
      Ig_3; Immunoglobulin domain
      cl11960
      Location:164250
      Ig; Immunoglobulin domain

    RNA

    1. XR_391039.4 RNA Sequence

      Related
      ENSMUST00000190646.7
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