Wdr90 WD repeat domain 90 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr90provided by MGI
Official Full Name: WD repeat domain 90provided by MGI
Primary source: MGI:MGI:1921267
See related: Ensembl:ENSMUSG00000073434 AllianceGenome:MGI:1921267
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1924; 3230401M21Rik
Summary: Predicted to be involved in cilium assembly. Predicted to be located in centrosome. Predicted to be active in centriole. Is expressed in choroid invagination; diencephalon roof plate; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Orthologous to human WDR90 (WD repeat domain 90). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 17.6), thymus adult (RPKM 16.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.94 cM

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26063708..26080489, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25844734..25861515, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

D17Aus57 (e-PCR), detects polymorphism
- UniSTS:142109

NoName (e-PCR)
- UniSTS:484970

AI551153 (e-PCR)
- UniSTS:166039

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD repeat-containing protein 90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163766.2 → NP_001157238.1 WD repeat-containing protein 90 isoform 1

Status: VALIDATED

Source sequence(s)

AC159277

Consensus CDS

CCDS50037.1

UniProtKB/TrEMBL

H7BX49

Related

ENSMUSP00000078426.9, ENSMUST00000079461.15

Conserved Domains (4) summary

COG2319
Location:1275 → 1698

WD40; WD40 repeat [General function prediction only]

pfam05018
Location:63 → 257

DUF667; Protein of unknown function (DUF667)

sd00039
Location:1304 → 1346

7WD40; WD40 repeat [structural motif]

cl02567
Location:777 → 1077

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001433407.1 → NP_001420336.1 WD repeat-containing protein 90 isoform 2

Status: VALIDATED

Source sequence(s)

AC159277

UniProtKB/Swiss-Prot

Q6ZPG2, Q80VI2, Q8BI97, Q8R3G7, Q921X4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

26063708..26080489 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_134124.1: Suppressed sequence

Description

NM_134124.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.