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    Pcsk2 proprotein convertase subtilisin/kexin type 2 [ Mus musculus (house mouse) ]

    Gene ID: 18549, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pcsk2provided by MGI
    Official Full Name
    proprotein convertase subtilisin/kexin type 2provided by MGI
    Primary source
    MGI:MGI:97512
    See related
    Ensembl:ENSMUSG00000027419 AllianceGenome:MGI:97512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC2; Nec2; SPC2; Nec-2; Phpp-2; 6330411F23Rik
    Summary
    Enables serine-type endopeptidase activity. Involved in nervous system development and protein processing. Acts upstream of or within proteolysis. Located in extracellular space. Is active in secretory granule. Is expressed in brain; endocrine gland; future brain; and gut. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 46.1), frontal lobe adult (RPKM 33.5) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Pcsk2 in Genome Data Viewer
    Location:
    2 G1; 2 70.89 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (143388053..143658204)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (143546133..143816284)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33599 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene proprotein convertase subtilisin/kexin type 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05885 Neighboring gene STARR-seq mESC enhancer starr_05886 Neighboring gene STARR-seq mESC enhancer starr_05887 Neighboring gene STARR-seq mESC enhancer starr_05889 Neighboring gene proprotein convertase subtilisin/kexin type 2, opposite strand 2 Neighboring gene predicted gene, 52527 Neighboring gene STARR-positive B cell enhancer ABC_E4506 Neighboring gene beaded filament structural protein 1, in lens-CP94 Neighboring gene ribosomal protein S13, pseudogene 6 Neighboring gene predicted gene, 33648

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in dendrite  
    located_in dendrite  
    located_in endoplasmic reticulum lumen  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    is_active_in membrane  
    located_in membrane  
    located_in membrane  
    is_active_in neuron projection  
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in perikaryon  
    located_in perikaryon  
    is_active_in secretory granule PubMed 
    located_in secretory granule  
    located_in secretory granule lumen  
    located_in transport vesicle  

    General protein information

    Preferred Names
    neuroendocrine convertase 2
    Names
    KEX2-like endoprotease 2
    NEC 2
    prohormone convertase 2
    proprotein convertase 2
    NP_032818.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008792.4NP_032818.1  neuroendocrine convertase 2 precursor

      See identical proteins and their annotated locations for NP_032818.1

      Status: VALIDATED

      Source sequence(s)
      AK158598, AL807801, BC057348
      Consensus CDS
      CCDS16810.1
      UniProtKB/Swiss-Prot
      P21661, Q80WU1
      UniProtKB/TrEMBL
      Q3TYM6, Q547J8
      Related
      ENSMUSP00000028905.10, ENSMUST00000028905.10
      Conserved Domains (4) summary
      cd04059
      Location:121417
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:157434
      Peptidase_S8; Subtilase family
      pfam01483
      Location:503590
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:32108
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      143388053..143658204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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