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    Ror1 receptor tyrosine kinase-like orphan receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 26563, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ror1provided by MGI
    Official Full Name
    receptor tyrosine kinase-like orphan receptor 1provided by MGI
    Primary source
    MGI:MGI:1347520
    See related
    Ensembl:ENSMUSG00000035305 AllianceGenome:MGI:1347520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntrkr1; 2810404D04Rik
    Summary
    This gene encodes a receptor tyrosine kinase that has been implicated in nervous system development, specifically in the maintenance of neural progenitor cell fate, neurite extension and synapse formation. The encoded protein, likely a pseudokinase that lacks catalytic activity, may also regulate adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in bladder adult (RPKM 2.2), limb E14.5 (RPKM 1.7) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Ror1 in Genome Data Viewer
    Location:
    4 C6; 4 45.71 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (99952988..100302003)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (100095791..100444806)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6193 Neighboring gene phosphoglucomutase 1 Neighboring gene STARR-seq mESC enhancer starr_10877 Neighboring gene predicted gene, 35701 Neighboring gene predicted gene 12701 Neighboring gene STARR-seq mESC enhancer starr_10879 Neighboring gene predicted gene, 35760 Neighboring gene STARR-seq mESC enhancer starr_10880 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2U (putative) Neighboring gene ubiquitin-conjugating enzyme E2U (putative), opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables Wnt receptor activity  
    enables Wnt receptor activity  
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    NOT enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in astrocyte development  
    involved_in astrocyte development  
    involved_in cell population proliferation  
    NOT involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in inner ear development PubMed 
    involved_in multicellular organism development  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in sensory perception of sound  
    involved_in sensory perception of sound  
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon terminus PubMed 
    located_in cell surface  
    located_in cell surface  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane PubMed 
    part_of receptor complex  
    part_of receptor complex  
    located_in stress fiber  
    located_in stress fiber  

    General protein information

    Preferred Names
    inactive tyrosine-protein kinase transmembrane receptor ROR1
    Names
    neurotrophic tyrosine kinase, receptor-related 1
    tyrosine-protein kinase transmembrane receptor ROR1
    NP_001299619.1
    NP_038873.2
    XP_006503184.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312690.1NP_001299619.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in an early stop codon and a novel 3' UTR compared to variant 1. The encoded isoform (2) has a shorter C-terminus than isoform 1.
      Source sequence(s)
      AK049369, AL670246, BB652069
      UniProtKB/TrEMBL
      Q501P6
      Conserved Domains (2) summary
      smart00408
      Location:72137
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:63148
      I-set; Immunoglobulin I-set domain
    2. NM_013845.5NP_038873.2  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_038873.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK049369, AL670246, BB652069
      Consensus CDS
      CCDS18389.1
      UniProtKB/Swiss-Prot
      Q8BG10, Q9Z139
      UniProtKB/TrEMBL
      Q8BNP9
      Related
      ENSMUSP00000048171.6, ENSMUST00000039630.6
      Conserved Domains (6) summary
      cd00096
      Location:75143
      Ig; Immunoglobulin domain
      cd07467
      Location:166307
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:311393
      KR; Kringle domain
      pfam07679
      Location:63148
      I-set; Immunoglobulin I-set domain
      cd05090
      Location:467749
      PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
      pfam07714
      Location:473746
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      99952988..100302003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503121.2XP_006503184.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1

      Conserved Domains (3) summary
      smart00130
      Location:123205
      KR; Kringle domain
      cd05090
      Location:279561
      PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
      cl02447
      Location:1119
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
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