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    Krt42 keratin 42 [ Mus musculus (house mouse) ]

    Gene ID: 68239, updated on 9-Dec-2024

    Summary

    Official Symbol
    Krt42provided by MGI
    Official Full Name
    keratin 42provided by MGI
    Primary source
    MGI:MGI:1915489
    See related
    Ensembl:ENSMUSG00000053654 AllianceGenome:MGI:1915489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K42; K17n; Ka22; CK-42; ecat6; 2410039E07Rik
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in keratin filament. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Krt42 in Genome Data Viewer
    Location:
    11 D; 11 63.44 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100153708..100160777, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100262882..100269951, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 16 Neighboring gene keratin 17 Neighboring gene STARR-seq mESC enhancer starr_30718 Neighboring gene predicted gene 14206 Neighboring gene STARR-seq mESC enhancer starr_30725 Neighboring gene STARR-positive B cell enhancer ABC_E1148 Neighboring gene STARR-positive B cell enhancer ABC_E3019 Neighboring gene eukaryotic translation initiation factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in epithelial cell differentiation  
    involved_in intermediate filament organization  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytoskeleton  
    located_in intermediate filament  

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 42
    Names
    cytokeratin-42
    keratin 17n
    predicted ortholog of type I keratin KA22
    type I keratin KA22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212483.3NP_997648.2  keratin, type I cytoskeletal 42

      See identical proteins and their annotated locations for NP_997648.2

      Status: VALIDATED

      Source sequence(s)
      AL590873
      Consensus CDS
      CCDS25416.1
      UniProtKB/Swiss-Prot
      A7MAW4, Q2M1G8, Q6IFX2, Q6SEK1
      Related
      ENSMUSP00000017270.7, ENSMUST00000017270.8
      Conserved Domains (2) summary
      pfam00038
      Location:93404
      Filament; Intermediate filament protein
      pfam07195
      Location:236358
      FliD_C; Flagellar hook-associated protein 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100153708..100160777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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