Rab11fip5 RAB11 family interacting protein 5 (class I) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab11fip5provided by MGI
Official Full Name: RAB11 family interacting protein 5 (class I)provided by MGI
Primary source: MGI:MGI:1098586
See related: Ensembl:ENSMUSG00000051343 AllianceGenome:MGI:1098586
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GAF1; RIP11; D6Ertd32e; 9130206P09Rik
Summary: Predicted to enable gamma-tubulin binding activity. Involved in insulin secretion involved in cellular response to glucose stimulus; postsynaptic neurotransmitter receptor internalization; and regulated exocytosis. Acts upstream of or within cellular response to type II interferon. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human RAB11FIP5 (RAB11 family interacting protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 59.8), ovary adult (RPKM 19.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 37.35 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (85311944..85351663, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (85334962..85374684, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.
Title: RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.
the ability of insulin to increase the appearance of Rip11 at the cell surface involves an inhibition of Rip11 internalisation from the plasma membrane
Title: Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event.
The results of this study suggest a requirement for Rab11Fip5, and presumably Rab11, during Hippocampal Long-Term Depression.
Title: Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression.
Delivery of Rab11-containing membrane stores effects broad and functional pseudopods during FcgammaR-mediated phagocytosis in mutant cultures of kinesin 5B-expressing cells.
Title: Kinesin 5B is necessary for delivery of membrane and receptors during FcγR-mediated phagocytosis.
Study shows that both Rab11 and its effector Rip11 participate in insulin granule exocytosis and that Rip11, as a substrate of PKA, regulates the potentiation of exocytosis by cAMP in pancreatic beta-cells.
Title: Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis.
Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulatd glucose uptake in adipocytes.
Title: Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C75969 (e-PCR)
- UniSTS:159526

RH126025 (e-PCR)
- UniSTS:162737

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables gamma-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adiponectin secretion	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab11 family-interacting protein 5

Names: rab11-FIP5; rab11-interacting protein Rip11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003955.2 → NP_001003955.1 rab11 family-interacting protein 5 isoform 1

See identical proteins and their annotated locations for NP_001003955.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK129230, BC044833

Consensus CDS

CCDS85083.1

UniProtKB/TrEMBL

A0A0N4SW73, Q6ZQ33

Related

ENSMUSP00000145402.2, ENSMUST00000204087.2

Conserved Domains (2) summary

pfam09457
Location:1266 → 1312

RBD-FIP; FIP domain

cl14603
Location:21 → 167

C2; C2 domain
NM_177466.4 → NP_803417.3 rab11 family-interacting protein 5 isoform 2

See identical proteins and their annotated locations for NP_803417.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AK129230, BC044833

Consensus CDS

CCDS20292.1

UniProtKB/Swiss-Prot

C4IXU4, Q8R361

Related

ENSMUSP00000058305.8, ENSMUST00000060837.10

Conserved Domains (2) summary

pfam09457
Location:593 → 639

RBD-FIP; FIP domain

cl14603
Location:21 → 167

C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

85311944..85351663 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506366.3 → XP_006506429.1 rab11 family-interacting protein 5 isoform X1

UniProtKB/TrEMBL

Q6ZQ33

Conserved Domains (2) summary

pfam09457
Location:1166 → 1212

RBD-FIP; FIP domain

cl14603
Location:21 → 167

C2; C2 domain