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    Srg2 Sting-regulated gene 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srg2provided by FlyBase
    Official Full Name
    Sting-regulated gene 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0262007
    Locus tag
    Dmel_CG42825
    See related
    AllianceGenome:FB:FBgn0262007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.30; CG42825; CG6640; Dmel\CG42825; GH19118; srg2
    Old locus tag
    Dmel_CG6640
    Summary
    Predicted to enable hexose transmembrane transporter activity. Involved in defense response to virus. Predicted to be located in membrane. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut; and embryonic/larval midgut primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Srg2 in Genome Data Viewer
    Location:
    67D8-67D8; 3-32 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10095754..10098115, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10088854..10091215, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Slavik KM, et al. Nature, 2021 Sep. PMID 34261127, Free PMC Article
    2. Two cGAS-like receptors induce antiviral immunity in Drosophila. Holleufer A, et al. Nature, 2021 Sep. PMID 34261128
    3. New candidate genes for sex-comb divergence between Drosophila mauritiana and Drosophila simulans. Graze RM, et al. Genetics, 2007 Aug. PMID 17565959, Free PMC Article
    4. 2'3'-cGAMP triggers a STING- and NF-κB-dependent broad antiviral response in Drosophila. Cai H, et al. Sci Signal, 2020 Dec 1. PMID 33262294
    5. Drug induces depression-like phenotypes and alters gene expression profiles in Drosophila. Jiang MD, et al. Brain Res Bull, 2017 Jun. PMID 28625786

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c10097358-10097329 mobile_element_type = transposon:INE-1{}5084

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hexose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hexose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sting-regulated gene 2
    Names
    CG42825-PA
    Srg2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10095754..10098115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168396.2 → NP_729590.1  Sting-regulated gene 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961K4
      Related
      FBpp0292840
      Conserved Domains (1) summary
      cd06174
      Location:116 → 490
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961K4 Q961K4

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