CtBP C-terminal Binding Protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CtBPprovided by FlyBase
Official Full Name: C-terminal Binding Proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0020496
Locus tag: Dmel_CG7583
See related: AllianceGenome:FB:FBgn0020496
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0256/16; 256/16; BcDNA:GH07572; CG7583; ctbp; CTBP; dCtBP; Dm-CtBP; Dmel\CG7583; EP(3)3528; G9; l(3)03463; l(3)03464; l(3)87De; l(3)87DE; l(3)G9; RE01030; RE61183
Summary: Enables DNA-binding transcription factor binding activity; protein homodimerization activity; and transcription coregulator activity. Involved in several processes, including regulation of canonical Wnt signaling pathway; regulation of transcription by RNA polymerase II; and sensory organ precursor cell fate determination. Located in nucleus. Part of ISWI-type complex. Colocalizes with polytene chromosome. Is expressed in several structures, including adult head; antennal disc; epithelium; eye disc anterior to the morphogenetic furrow; and female germline cell. Orthologous to human CTBP1 (C-terminal binding protein 1) and CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87D8-87D9; 3-53 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13011649..13026275)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8837371..8851997)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor.
Title: A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor.
Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.
Title: Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.
Data show separable and cell-type-specific functions of Groucho (Gro) and C-terminal binding protein (CtBP) in a Notch signaling cascade involved lateral inhibition process.
Title: Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem Cell Differentiation in Drosophila.
Thus, CtBP stabilizes cell fates following damage by opposing the destabilizing effects of the JNK/AP-1 and JAK/STAT pathways.
Title: CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs.
Here we provide evidence that although wild type CtBP negatively and dominantly influences Dpp signaling in fly presumptive wings, mutant CtBP unable to form dimer does not, indicating that dimerization is required for the repression role of CtBP in Dpp signaling in vivo.
Title: CtBP represses Dpp signaling as a dimer.
We found that TCF7L1 recruits the C-terminal binding protein (CtBP) and histone deacetylase 1 (HDAC1) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1, TCF7L2 and beta-catenin occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
Title: TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells.
Drosophila CtBP (dCtBP) was identified as a binding partner of Diap1; whether the interaction between Diap1 and dCtBP also occurs in human cells was tested.
Title: C-terminal binding protein-mediated transcriptional repression is regulated by X-linked inhibitor of apoptosis protein.
Data show that the differential recruitment of the co-repressors Gro and CtBP by H in a context-dependent manner ensures fine tuning of Notch signaling activity during eye development.
Title: Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila.
These results support a model where CtBP is a gene-specific regulator of Wingless signalling, with some targets requiring CtBP dimers for inhibition while other targets utilize CtBP monomers for activation of their expression.
Title: The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets.
Results indicate that the structural and enzymatic features of C-terminal binding protein are critical for modulating this protein's activity in diverse developmental settings.
Title: Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ISWI-type complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-terminal binding protein

Names: C-terminal-Binding-Protein; C-terminal-binding protein; CG7583-PA; CG7583-PB; CG7583-PC; CG7583-PD; CG7583-PE; CG7583-PF; CG7583-PG; CG7583-PH; CG7583-PI; CG7583-PJ; CtBP-PA; CtBP-PB; CtBP-PC; CtBP-PD; CtBP-PE; CtBP-PF; CtBP-PG; CtBP-PH; CtBP-PI; CtBP-PJ; drosophila C-terminal binding protein; lethal(3)87De

NP_001014617.1

EC 1.1.1.-

NP_001262520.1

EC 1.1.1.-

NP_001262521.1

EC 1.1.1.-

NP_001262522.1

EC 1.1.1.-

NP_001262523.1

EC 1.1.1.-

NP_001262524.1

EC 1.1.1.-

NP_524336.2

EC 1.1.1.-

NP_731762.1

EC 1.1.1.-

NP_731763.1

EC 1.1.1.-

NP_731764.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13011649..13026275

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014617.2 → NP_001014617.1 C-terminal binding protein, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014617.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O46036, O61283, Q59DX5, Q95SQ8, Q9VG02

Conserved Domains (2) summary

COG1052
Location:45 → 354

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 345

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001275593.1 → NP_001262522.1 C-terminal binding protein, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262522.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGZ7

Conserved Domains (2) summary

COG1052
Location:45 → 351

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 342

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001275595.1 → NP_001262524.1 C-terminal binding protein, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262524.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFT4

Conserved Domains (2) summary

COG1052
Location:45 → 351

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 342

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001275594.1 → NP_001262523.1 C-terminal binding protein, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262523.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFX5

Conserved Domains (2) summary

COG1052
Location:45 → 351

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 342

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001275591.2 → NP_001262520.1 C-terminal binding protein, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262520.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGG9

Conserved Domains (2) summary

COG0111
Location:26 → 352

SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 342

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_169491.2 → NP_731763.1 C-terminal binding protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731763.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V2S3

Related

FBpp0082168

Conserved Domains (2) summary

COG1052
Location:45 → 354

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 345

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_079612.3 → NP_524336.2 C-terminal binding protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524336.2

Status: REVIEWED

UniProtKB/TrEMBL

A4V2S3

Related

FBpp0082167

Conserved Domains (2) summary

COG1052
Location:45 → 354

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 345

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_169490.2 → NP_731762.1 C-terminal binding protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731762.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V2S3

Related

FBpp0082169

Conserved Domains (2) summary

COG1052
Location:45 → 354

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 345

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001275592.1 → NP_001262521.1 C-terminal binding protein, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262521.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHB2

Conserved Domains (2) summary

COG1052
Location:45 → 351

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 342

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_169492.2 → NP_731764.1 C-terminal binding protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731764.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V2S3

Related

FBpp0082170

Conserved Domains (2) summary

COG1052
Location:45 → 354

LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:28 → 345

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KFT4		A0A0B4KFT4
A0A0B4KFX5		A0A0B4KFX5
A0A0B4KGG9		A0A0B4KGG9
A0A0B4KGZ7		A0A0B4KGZ7
A0A0B4KHB2		A0A0B4KHB2
A4V2S3		A4V2S3
O46036.3		O46036