U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Serpina4-ps1 serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1 [ Mus musculus (house mouse) ]

    Gene ID: 321018, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Serpina4-ps1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1provided by MGI
    Primary source
    MGI:MGI:2448363
    See related
    Ensembl:ENSMUSG00000120841 AllianceGenome:MGI:2448363
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Klst; KALps
    Summary
    Is expressed in liver; spleen; and thymus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver E18 (RPKM 43.9) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Serpina4-ps1 in Genome Data Viewer
    Location:
    12 E; 12 53.23 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104044218..104053179)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104077959..104086920)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Neighboring gene predicted gene, 31271 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 5 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation. Ma C, et al. Int J Oncol, 2017 Jun. PMID 28440474, Free PMC Article
    2. Antiangiogenic and antineuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway. Liu X, et al. Diabetes, 2013 Dec. PMID 23884893, Free PMC Article
    3. Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway. Guo Y, et al. J Cell Mol Med, 2018 Sep. PMID 29992759, Free PMC Article
    4. Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity. Lu L, et al. Cancer Lett, 2007 Nov 8. PMID 17714861
    5. A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. Forsyth S, et al. Genomics, 2003 Mar. PMID 12659817

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endogenous kallistatin through novel mechanisms protects against endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway.
      Title: Kallistatin attenuates endothelial senescence by modulating Let-7g-mediated miR-34a-SIRT1-eNOS pathway.
    2. our results showed that the lymphatic vessel density (LVD) was reduced in lung and stomach sections from kallistatin-overexpressing transgenic mice
      Title: Kallistatin exerts anti-lymphangiogenic effects by inhibiting lymphatic endothelial cell proliferation, migration and tube formation.
    3. KBP reduces expression of VEGF and HIF-1alpha nuclear translocation
      Title: Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Other Names

    • kallistatin related protein
    • serine (or cysteine) proteinase inhibitor, clade A, member 4, pseudogene 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002861.2 RNA Sequence

      Status: INFERRED

      Source sequence(s)
      AC114552, AC142112
      Related
      ENSMUST00000311839.1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104044218..104053179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177315.1: Suppressed sequence

      Description
      NM_177315.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.