Aldh3b2 aldehyde dehydrogenase 3 family, member B2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aldh3b2provided by MGI
Official Full Name: aldehyde dehydrogenase 3 family, member B2provided by MGI
Primary source: MGI:MGI:2147613
See related: Ensembl:ENSMUSG00000075296 AllianceGenome:MGI:2147613
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C130048D07Rik
Summary: Enables aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Located in lipid droplet. Is expressed in several structures, including genitourinary system; integumental system; limb; sensory organ; and tail. Orthologous to human ALDH3B2 (aldehyde dehydrogenase 3 family member B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 45.8), stomach adult (RPKM 24.0) and 10 other tissues See more
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Genomic context

Location:: 19 A; 19 3.69 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4022328..4031665)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (3972328..3981665)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome.
Title: Impaired Skin Barrier Function Due to Reduced ω-O-Acylceramide Levels in a Mouse Model of Sjögren-Larsson Syndrome.
ALDH3B2 acts to remove lipid-derived aldehydes in lipid droplets generated via oxidative stress as a quality control mechanism.
Title: Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487386

AI848594 (e-PCR)
- UniSTS:166118

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aldehyde metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within aldehyde metabolic process	IC Inferred by Curator more info	PubMed
involved_in ethanol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aldehyde dehydrogenase family 3 member B2

Names: aldehyde dehydrogenase 8; long-chain fatty aldehyde dehydrogenase

NP_001170909.1

EC 1.2.1.3

EC 1.2.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.