Rev1 DNA polymerase Rev1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rev1provided by FlyBase
Official Full Name: DNA polymerase Rev1provided by FlyBase
Primary source: FLYBASE:FBgn0035150
Locus tag: Dmel_CG12189
See related: AllianceGenome:FB:FBgn0035150
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF47401; CG12189; Dmel\CG12189; DmRev1; DmREV1; drev1; dRev1; dREV1; rev1; REV1
Summary: Predicted to enable DNA-directed DNA polymerase activity and deoxycytidyl transferase activity. Involved in DNA synthesis involved in double-strand break repair via homologous recombination and regulation of double-strand break repair via homologous recombination. Predicted to be located in replication fork. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61C8-61C8; 3-0.5 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (654363..657971)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (654363..657971)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

kinetic basis for nucleotide selection by human Rev1, a unique nucleotidyl transferase that uses a protein template-directed mechanism to preferentially instruct dCTP incorporation
Title: Kinetic basis of nucleotide selection employed by a protein template-dependent DNA polymerase.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables deoxycytidyl transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxycytidyl transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA synthesis involved in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in error-free translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in error-prone translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in error-prone translesion synthesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA polymerase Rev1

Names: CG12189-PA; Rev1 DNA directed polymerase; Rev1-PA; UV-revertible gene 1

NP_612047.1

EC 2.7.7.-

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

654363..657971

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_138203.3 → NP_612047.1 DNA polymerase Rev1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_612047.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A9UNE7, Q8T9I8, Q9W0P2

Related

FBpp0072456

Conserved Domains (3) summary

cd01701
Location:218 → 676

PolY_Rev1; DNA polymerase Rev1

cd12145
Location:890 → 985

Rev1_C; C-terminal domain of the Y-family polymerase Rev1

cd17719
Location:39 → 121

BRCT_Rev1; BRCT domain of DNA repair protein Rev1 and similar proteins