AP-1sigma Adaptor Protein complex 1, sigma subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: AP-1sigmaprovided by FlyBase
Official Full Name: Adaptor Protein complex 1, sigma subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0039132
Locus tag: Dmel_CG5864
See related: AllianceGenome:FB:FBgn0039132
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AP-1sigma1; AP-1[sigma]; AP1sigma; AP1sigma1; aps1; cg5864; CG5864; Dmel\CG5864; sigma1
Summary: Enables clathrin adaptor activity. Involved in axon guidance; compound eye photoreceptor development; and intracellular transport. Part of AP-1 adaptor complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in MEDNIK syndrome; psoriasis 15; and syndromic X-linked intellectual disability 5. Orthologous to several human genes including AP1S2 (adaptor related protein complex 1 subunit sigma 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23958651..23962555)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19784373..19788277)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IEA Inferred from Electronic Annotation more info
enables clathrin adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables clathrin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of AP-1 adaptor complex	IEA Inferred from Electronic Annotation more info
part_of AP-1 adaptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of AP-1 adaptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
part_of membrane coat	IEA Inferred from Electronic Annotation more info

Names: AP-1sigma-PA; AP-1sigma-PB; AP-1sigma-PC; AP-1sigma-PD; CG5864-PA; CG5864-PB; CG5864-PC; CG5864-PD

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