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    RanGAP Ran GTPase activating protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35223, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RanGAPprovided by FlyBase
    Official Full Name
    Ran GTPase activating proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003346
    Locus tag
    Dmel_CG9999
    See related
    AllianceGenome:FB:FBgn0003346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9999; CT28175; Dmel\CG9999; dmRanGAP; dRanGAP; Ran; rangap; ranGap; ranGAP; Rangap; RanGap; RanGap1; RanGAP1; RGP1_DROME; Scl; Sd; SD; Sd-RanGap; Sd-RanGAP
    Summary
    Enables GTPase activator activity and RNA binding activity. Involved in protein export from nucleus and regulation of nucleocytoplasmic transport. Located in perinuclear region of cytoplasm. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; endoderm anlage; head epidermis primordium; and mesoderm. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RanGAP in Genome Data Viewer
    Location:
    37E1-37E1; 2-54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19441959..19447317)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19441959..19447317)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RtcB RNA ligase Neighboring gene Rab9 Neighboring gene uncharacterized protein Neighboring gene Heparan sulfate 2-O-sulfotransferase Neighboring gene Topoisomerase 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selfish genes and meiotic drive. Hurst LD. Nature, 1998 Jan 15. PMID 9440681
    2. The Y Chromosome as a Battleground for Intragenomic Conflict. Bachtrog D. Trends Genet, 2020 Jul. PMID 32448494, Free PMC Article
    3. Dynamics of spermiogenesis in Drosophila melanogaster. I. Individualization process. Tokuyasu KT, et al. Z Zellforsch Mikrosk Anat, 1972. PMID 4622067
    4. Dynamics of spermiogenesis in Drosophila melanogaster. II. Coiling process. Tokuyasu KT, et al. Z Zellforsch Mikrosk Anat, 1972. PMID 4625686
    5. Aging effect on the phenomenon of segregation distortion in Drosophila melanogaster. Hiraizumi Y, et al. Genetics, 1969 Sep. PMID 5365286, Free PMC Article

    See all (182) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sexual selection can partly explain low frequencies of Segregation Distorter alleles.
      Title: Sexual selection can partly explain low frequencies of Segregation Distorter alleles.
    2. A cross-eyed geneticist's view VI. Segregation distortion in Drosophila melanogaster: Recent progress in solving 'an esoteric puzzle'.
      Title: A cross-eyed geneticist's view VI. Segregation distortion in Drosophila melanogaster: Recent progress in solving 'an esoteric puzzle'.
    3. Fitness consequences of the selfish supergene Segregation Distorter.
      Title: Fitness consequences of the selfish supergene Segregation Distorter.
    4. in larval brain neuroblasts, an intrinsic mechanism facilitates import and export of Pros across the nuclear envelope via a Ran-mediated nucleocytoplasmic transport system.
      Title: RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain.
    5. molecular and evolutionary genetics of Segregation Distorter
      Title: The selfish Segregation Distorter gene complex of Drosophila melanogaster.
    6. Sd, the primary gene responsible for segregation distortion, encodes a mutant RanGAP, a key protein in the Ran signaling pathway required for nuclear transport and other nuclear functions.
      Title: Closing the (Ran)GAP on segregation distortion in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic chromosome segregation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear export IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ran GTPase activating protein
    Names
    CG9999-PA
    CG9999-PB
    CG9999-PC
    Ran-GTPase activating protein
    RanGAP-PA
    RanGAP-PB
    RanGAP-PC
    segregation distorter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19441959..19447317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057364.4 → NP_476712.1  Ran GTPase activating protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476712.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIW3, Q9XZI5
      UniProtKB/TrEMBL
      A0A0E3X848, M9PBD9
      Related
      FBpp0080775
      Conserved Domains (2) summary
      cd00116
      Location:50 → 337
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:45 → 77
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_001273650.1 → NP_001260579.1  Ran GTPase activating protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0E3X848, M9PD65
      Conserved Domains (2) summary
      cd00116
      Location:42 → 329
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:37 → 69
      LRR_RI; leucine-rich repeat [structural motif]

    3. NM_001273649.1 → NP_001260578.1  Ran GTPase activating protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260578.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIW3, Q9XZI5
      UniProtKB/TrEMBL
      A0A0E3X848, M9PBD9
      Conserved Domains (2) summary
      cd00116
      Location:50 → 337
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:45 → 77
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBD9 M9PBD9
    M9PD65 M9PD65
    Q9VIW3.1 Q9VIW3

    Gene LinkOut

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