Fcrl2 Fc receptor like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcrl2provided by MGI
Official Full Name: Fc receptor like 2provided by MGI
Primary source: MGI:MGI:1933397
See related: Ensembl:ENSMUSG00000015852 AllianceGenome:MGI:1933397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IgSR; Msr2; Fcrh2; Fcrls; IFGP2; MMAN-g; FcRH2sc; moFcRH2sc; 9330158F12; 2810439C17Rik
Summary: Predicted to enable protein phosphatase binding activity; signaling adaptor activity; and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to human FCRL2 (Fc receptor like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in mammary gland adult (RPKM 8.9), subcutaneous fat pad adult (RPKM 7.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.19 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87158318..87171046, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87250736..87263765, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transgenic Targeting of Fcrls Creates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated Specificity.
Title: Transgenic Targeting of Fcrls Creates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated Specificity.
Class A scavenger receptor-1/2 facilitates the uptake of bovine milk exosomes in murine bone marrow-derived macrophages and C57BL/6J mice.
Title: Class A scavenger receptor-1/2 facilitates the uptake of bovine milk exosomes in murine bone marrow-derived macrophages and C57BL/6J mice.
SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence
Title: Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (1) 1 citation

General gene information

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Markers

D3Dcr12 (e-PCR), detects polymorphism
- UniSTS:507662

D3Mit187 (e-PCR), detects polymorphism
- UniSTS:129608

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Fc receptor-like protein 2

Names: Fc receptor-like S, scavenger receptor; immunoglobulin scavenger receptor; macrophage scavenger receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419220.1 → NP_001406149.1 Fc receptor-like protein 2 precursor

Status: VALIDATED

Source sequence(s)

AC091682

UniProtKB/TrEMBL

Q9EQY5
NM_030707.4 → NP_109632.2 Fc receptor-like protein 2 precursor

See identical proteins and their annotated locations for NP_109632.2

Status: VALIDATED

Source sequence(s)

AC091682

Consensus CDS

CCDS38471.1

UniProtKB/TrEMBL

Q91YK7, Q9EQY5

Related

ENSMUSP00000088508.5, ENSMUST00000090986.11

Conserved Domains (5) summary

smart00202
Location:402 → 502

SR; Scavenger receptor Cys-rich

smart00409
Location:316 → 395

IG; Immunoglobulin

smart00410
Location:224 → 302

IG_like; Immunoglobulin like

pfam13927
Location:112 → 181

Ig_3; Immunoglobulin domain

cl11960
Location:19 → 85

Ig; Immunoglobulin domain