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    Fur2 Furin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fur2provided by FlyBase
    Official Full Name
    Furin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0004598
    Locus tag
    Dmel_CG18734
    See related
    AllianceGenome:FB:FBgn0004598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154521_at; CG18734; CG4235; Dfur2; Dfurin2; Dmel\CG18734; DMH#11; fur2; FUR2; furin; Furin
    Summary
    Enables serine-type endopeptidase activity. Involved in R8 cell fate specification and negative regulation of secretion. Predicted to be located in plasma membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fur2 in Genome Data Viewer
    Location:
    14C1-14C2; 1-53 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16373086..16381782)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16267119..16275815)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Q Neighboring gene no on or off transient A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif. Roebroek AJ, et al. J Biol Chem, 1992 Aug 25. PMID 1512259
    2. cDNA sequence of a Drosophila melanogaster gene, Dfur1, encoding a protein structurally related to the subtilisin-like proprotein processing enzyme furin. Roebroek AJ, et al. FEBS Lett, 1991 Sep 9. PMID 1915835
    3. Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2. De Bie I, et al. J Biol Chem, 1995 Jan 20. PMID 7836354
    4. The Dfur2 gene of Drosophila melanogaster: genetic organization, expression during embryogenesis, and pro-protein processing activity of its translational product Dfurin2. Roebroek AJ, et al. DNA Cell Biol, 1995 Mar. PMID 7880443
    5. Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene. Roebroek AJ, et al. EMBO J, 1993 May. PMID 8491178, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study demonstrates that Furin proteases are required for Trk cleavage, and show that the Furin 1 and Furin 2 proteases act redundantly in terminal patterning in the Drosophila embryo.
      Title: Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini.
    2. furin-cleavage sites in BMP2/4/DPP precursors are tolerant to mutations acquired through evolution and have adapted to different systems in diversified species
      Title: The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R8 cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    furin 2
    Names
    CG18734-PA
    CG18734-PB
    CG18734-PC
    CG18734-PD
    CG18734-PE
    CG18734-PF
    CG18734-PG
    CG18734-PH
    CG18734-PI
    Dfurin2
    Fur2-PA
    Fur2-PB
    Fur2-PC
    Fur2-PD
    Fur2-PE
    Fur2-PF
    Fur2-PG
    Fur2-PH
    Fur2-PI
    Furin-like protease
    furin2
    NP_001162773.1
    NP_001162774.1
    NP_523368.2
    NP_727963.1
    NP_727964.1
    NP_727965.1
    NP_727966.1
    NP_727967.1
    NP_996486.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16373086..16381782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206763.2 → NP_996486.1  furin 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996486.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4M0, A4V4M2, P30432, Q24301, Q5BI10, Q8SZS2
      Conserved Domains (8) summary
      cd04059
      Location:375 → 671
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1208 → 1252
      FU; Furin-like repeats
      cd00064
      Location:1113 → 1160
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:408 → 697
      Peptidase_S8; Subtilase family
      pfam00757
      Location:963 → 1123
      Furin-like; Furin-like cysteine rich region
      pfam01483
      Location:758 → 846
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:1065 → 1229
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain

    2. NM_167510.3 → NP_727967.1  furin 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4M0, A4V4M2, P30432, Q24301, Q5BI10, Q8SZS2
      Related
      FBpp0074041
      Conserved Domains (8) summary
      cd04059
      Location:375 → 671
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1208 → 1252
      FU; Furin-like repeats
      cd00064
      Location:1113 → 1160
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:408 → 697
      Peptidase_S8; Subtilase family
      pfam00757
      Location:963 → 1123
      Furin-like; Furin-like cysteine rich region
      pfam01483
      Location:758 → 846
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:1065 → 1229
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain

    3. NM_167506.3 → NP_727963.1  furin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30432
      Related
      FBpp0074038
      Conserved Domains (8) summary
      cd04059
      Location:375 → 674
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1211 → 1255
      FU; Furin-like repeats
      cd00064
      Location:1116 → 1163
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:411 → 700
      Peptidase_S8; Subtilase family
      pfam00757
      Location:966 → 1126
      Furin-like; Furin-like cysteine rich region
      pfam01483
      Location:761 → 849
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:1068 → 1232
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain

    4. NM_001169302.2 → NP_001162773.1  furin 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJL5
      Conserved Domains (3) summary
      cd04059
      Location:375 → 586
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:408 → 586
      Peptidase_S8; Subtilase family
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain

    5. NM_078644.4 → NP_523368.2  furin 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523368.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4M0, A4V4M2, P30432, Q24301, Q5BI10, Q8SZS2
      Related
      FBpp0074039
      Conserved Domains (8) summary
      cd04059
      Location:375 → 671
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1208 → 1252
      FU; Furin-like repeats
      cd00064
      Location:1113 → 1160
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:408 → 697
      Peptidase_S8; Subtilase family
      pfam00757
      Location:963 → 1123
      Furin-like; Furin-like cysteine rich region
      pfam01483
      Location:758 → 846
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:1065 → 1229
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain

    6. NM_001169303.2 → NP_001162774.1  furin 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162774.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJL4
      Conserved Domains (8) summary
      cd04059
      Location:351 → 647
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1184 → 1228
      FU; Furin-like repeats
      cd00064
      Location:1089 → 1136
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:384 → 673
      Peptidase_S8; Subtilase family
      pfam00757
      Location:939 → 1099
      Furin-like; Furin-like cysteine rich region
      pfam01483
      Location:734 → 822
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:1041 → 1205
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain

    7. NM_167507.3 → NP_727964.1  furin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727964.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30432
      Related
      FBpp0074042
      Conserved Domains (8) summary
      cd04059
      Location:375 → 674
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1211 → 1255
      FU; Furin-like repeats
      cd00064
      Location:1116 → 1163
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:411 → 700
      Peptidase_S8; Subtilase family
      pfam00757
      Location:966 → 1126
      Furin-like; Furin-like cysteine rich region
      pfam01483
      Location:761 → 849
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:1068 → 1232
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain

    8. NM_167508.2 → NP_727965.1  furin 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30432
      Related
      FBpp0074040
      Conserved Domains (8) summary
      cd04059
      Location:375 → 674
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1211 → 1255
      FU; Furin-like repeats
      cd00064
      Location:1116 → 1163
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:411 → 700
      Peptidase_S8; Subtilase family
      pfam00757
      Location:966 → 1126
      Furin-like; Furin-like cysteine rich region
      pfam01483
      Location:761 → 849
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:1068 → 1232
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain

    9. NM_167509.3 → NP_727966.1  furin 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727966.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4M0, A4V4M2, P30432, Q24301, Q5BI10, Q8SZS2
      Related
      FBpp0074043
      Conserved Domains (8) summary
      cd04059
      Location:375 → 671
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:1208 → 1252
      FU; Furin-like repeats
      cd00064
      Location:1113 → 1160
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:408 → 697
      Peptidase_S8; Subtilase family
      pfam00757
      Location:963 → 1123
      Furin-like; Furin-like cysteine rich region
      pfam01483
      Location:758 → 846
      P_proprotein; Proprotein convertase P-domain
      pfam14843
      Location:1065 → 1229
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:242 → 318
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJL4 E1JJL4
    E1JJL5 E1JJL5
    P30432.2 P30432

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