Nsun2 NOP2-Sun domain family, member 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nsun2provided by FlyBase
Official Full Name: NOP2-Sun domain family, member 2provided by FlyBase
Primary source: FLYBASE:FBgn0026079
Locus tag: Dmel_CG6133
See related: AllianceGenome:FB:FBgn0026079
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6133; Dmel\CG6133; dNsun2; dNSUN2; EG:EG0007.9; nsun2; NSun2; NSUN2
Summary: Enables RNA binding activity. Involved in short-term memory and tRNA methylation. Located in nucleus. Is expressed in adult head; embryonic/larval hindgut; embryonic/larval proventriculus; organism; and spermatozoon. Used to study intellectual disability. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4A5-4A6; 1-6 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4111156..4113734, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4005189..4007767, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mutations in two (cytosine-5) RNA methyltransferases, Dnmt2 and NSun2, impact the accumulation of mobile element-derived sequences and DNA repeat integrity in Drosophila.
Title: Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats.
The highly conserved NSUN2 is not essential for survival, gross nervous-system function, or elementary behavior such as locomotion, whereas in both contexts, NSUN2 is apparently crucial for higher cognitive functioning.
Title: Mutations in NSUN2 cause autosomal-recessive intellectual disability.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0368 (e-PCR)
- UniSTS:4400

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables tRNA (cytidine-5-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (cytidine-5-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (cytidine-5-)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA methylation	IEA Inferred from Electronic Annotation more info
involved_in RNA methylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NOP2-Sun domain family, member 2

Names: CG6133-PA; NOP2-Sun domain family, member 2 ortholog; Nsun2-PA

NP_652007.1

EC 2.1.1.-

EC 2.1.1.202

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

4111156..4113734 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143750.3 → NP_652007.1 NOP2-Sun domain family, member 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652007.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O97427, Q9W4M9

Related

FBpp0070637

Conserved Domains (1) summary

COG0144
Location:13 → 433

RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]