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    CNTRL centriolin [ Homo sapiens (human) ]

    Gene ID: 11064, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CNTRLprovided by HGNC
    Official Full Name
    centriolinprovided by HGNC
    Primary source
    HGNC:HGNC:1858
    See related
    Ensembl:ENSG00000119397 MIM:605496; AllianceGenome:HGNC:1858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAN; CEP1; CEP110; bA165P4.1
    Summary
    This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 22.4), lymph node (RPKM 12.1) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CNTRL in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (121074955..121177610)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (133271062..133373637)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123837233..123939888)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28912 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123725569-123725752 Neighboring gene C5 3' UTR overlapping transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28913 Neighboring gene complement C5 Neighboring gene uncharacterized LOC124902261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28914 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123836497-123836693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28915 Neighboring gene NANOG hESC enhancer GRCh37_chr9:123883693-123884194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28917 Neighboring gene uncharacterized LOC124902357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:123963761-123964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28919 Neighboring gene RAB14, member RAS oncogene family Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene gelsolin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). Guasch G, et al. Blood, 2000 Mar 1. PMID 10688839
    2. A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. Gromley A, et al. J Cell Biol, 2003 May 12. PMID 12732615, Free PMC Article
    3. Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. Gromley A, et al. Cell, 2005 Oct 7. PMID 16213214
    4. Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization. Popovici C, et al. Cytogenet Cell Genet, 2000. PMID 10965126
    5. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. Ou YY, et al. J Cell Sci, 2002 May 1. PMID 11956314

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In this study, we present two new cases of CNTRL-FGFR1 fusion
      Title: Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia.
    2. CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models
      Title: Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. CEP110 is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC.
      Title: CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation.
    6. We propose that centriolin anchors protein complexes required for vesicle targeting and fusion and integrates membrane-vesicle fusion with abscission.
      Title: Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aorta development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coronary vasculature development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		  
    part_of centriolar subdistal appendage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in meiotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centriolin
    Names
    110 kDa centrosomal protein
    bA165P4.1 (ortholog of mouse Ma2a8)
    bA165P4.2 (centrosomal protein 1)
    centriole associated protein
    centrosomal protein 110kDa
    centrosomal protein of 110 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330762.2 → NP_001317691.1  centriolin isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL137068
      Consensus CDS
      CCDS83409.1
      UniProtKB/TrEMBL
      A0A8I5KY43
      Related
      ENSP00000362956.1, ENST00000373850.6

    2. NM_001369892.1 → NP_001356821.1  centriolin isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL137068
      UniProtKB/TrEMBL
      A0A8I5KY43
      Conserved Domains (2) summary
      TIGR02168
      Location:794 → 1608
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15240
      Location:624 → 747
      Pro-rich; Proline-rich

    3. NM_001369893.1 → NP_001356822.1  centriolin isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC006430, AL137068
      Consensus CDS
      CCDS94474.1
      UniProtKB/TrEMBL
      Q5JVD1
      Related
      ENSP00000362953.2, ENST00000373847.6
      Conserved Domains (6) summary
      COG1196
      Location:435 → 1132
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam15240
      Location:1176 → 1299
      Pro-rich; Proline-rich
      pfam14580
      Location:130 → 279
      LRR_9; Leucine-rich repeat
      cl29113
      Location:76 → 181
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. NM_001369894.1 → NP_001356823.1  centriolin isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC006430, AL137068
      Related
      ENST00000688832.1
      Conserved Domains (6) summary
      COG1196
      Location:454 → 1151
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam15240
      Location:1195 → 1318
      Pro-rich; Proline-rich
      pfam14580
      Location:130 → 279
      LRR_9; Leucine-rich repeat
      cl29113
      Location:76 → 181
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    5. NM_001369895.1 → NP_001356824.1  centriolin isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC006430, AL137068
      Conserved Domains (4) summary
      COG1196
      Location:268 → 965
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:4 → 27
      LRR_1; leucine-rich repeat [structural motif]
      pfam15240
      Location:1009 → 1132
      Pro-rich; Proline-rich
      pfam14580
      Location:4 → 112
      LRR_9; Leucine-rich repeat

    6. NM_001369896.1 → NP_001356825.1  centriolin isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC006430, AL137068
      Related
      ENST00000685174.1
      Conserved Domains (3) summary
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam14580
      Location:130 → 279
      LRR_9; Leucine-rich repeat
      cl29113
      Location:76 → 181
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    7. NM_007018.6 → NP_008949.4  centriolin isoform 1

      See identical proteins and their annotated locations for NP_008949.4

      Status: REVIEWED

      Source sequence(s)
      AC006430, AL137068
      Consensus CDS
      CCDS35118.1
      UniProtKB/Swiss-Prot
      A2A2Y1, B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q7Z7A1, Q8TEP3, Q9Y489
      UniProtKB/TrEMBL
      B2RP65
      Related
      ENSP00000362962.1, ENST00000373855.7
      Conserved Domains (9) summary
      COG4372
      Location:1320 → 1602
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:435 → 1119
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04523
      Location:1511 → 2206
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:126 → 167
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:148 → 205
      LRR_8; Leucine rich repeat
      pfam15240
      Location:1176 → 1299
      Pro-rich; Proline-rich
      cl19219
      Location:513 → 610
      DUF342; Protein of unknown function (DUF342)

    RNA

    1. NR_163191.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137068

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      121074955..121177610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422667.1 → XP_047278623.1  centriolin isoform X1

      UniProtKB/TrEMBL
      B2RP65

    2. XM_047422671.1 → XP_047278627.1  centriolin isoform X5

      UniProtKB/TrEMBL
      B2RP65

    3. XM_047422669.1 → XP_047278625.1  centriolin isoform X2

      UniProtKB/TrEMBL
      B2RP65

    4. XM_047422673.1 → XP_047278629.1  centriolin isoform X7

      UniProtKB/TrEMBL
      B2RP65

    5. XM_047422678.1 → XP_047278634.1  centriolin isoform X11

      UniProtKB/TrEMBL
      B2RP65

    6. XM_047422683.1 → XP_047278639.1  centriolin isoform X17

      UniProtKB/TrEMBL
      B2RP65

    7. XM_047422677.1 → XP_047278633.1  centriolin isoform X10

      UniProtKB/TrEMBL
      B2RP65

    8. XM_047422670.1 → XP_047278626.1  centriolin isoform X4

      UniProtKB/TrEMBL
      B2RP65

    9. XM_047422681.1 → XP_047278637.1  centriolin isoform X15

      UniProtKB/TrEMBL
      B2RP65

    10. XM_011518166.3 → XP_011516468.1  centriolin isoform X3

      See identical proteins and their annotated locations for XP_011516468.1

      UniProtKB/TrEMBL
      B2RP65
      Conserved Domains (9) summary
      COG4372
      Location:1320 → 1602
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:435 → 1119
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04523
      Location:1525 → 2221
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:126 → 167
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:148 → 205
      LRR_8; Leucine rich repeat
      pfam15240
      Location:1176 → 1299
      Pro-rich; Proline-rich
      cl19219
      Location:513 → 610
      DUF342; Protein of unknown function (DUF342)

    11. XM_006716940.4 → XP_006717003.1  centriolin isoform X13

      UniProtKB/TrEMBL
      B2RP65
      Conserved Domains (7) summary
      TIGR02168
      Location:1346 → 2160
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:126 → 167
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:148 → 205
      LRR_8; Leucine rich repeat
      pfam15240
      Location:1176 → 1299
      Pro-rich; Proline-rich
      cl19219
      Location:513 → 610
      DUF342; Protein of unknown function (DUF342)

    12. XM_017014224.3 → XP_016869713.1  centriolin isoform X21

      UniProtKB/TrEMBL
      B2RP65

    13. XM_011518170.3 → XP_011516472.1  centriolin isoform X12

      UniProtKB/TrEMBL
      B2RP65
      Conserved Domains (10) summary
      COG4372
      Location:1261 → 1543
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:435 → 1060
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04523
      Location:1466 → 2162
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:126 → 167
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:148 → 205
      LRR_8; Leucine rich repeat
      pfam15240
      Location:1117 → 1240
      Pro-rich; Proline-rich
      cl19219
      Location:513 → 610
      DUF342; Protein of unknown function (DUF342)
      cl23943
      Location:2057 → 2147
      PCRF; PCRF domain

    14. XM_011518168.3 → XP_011516470.1  centriolin isoform X6

      UniProtKB/TrEMBL
      B2RP65
      Conserved Domains (8) summary
      COG4372
      Location:1295 → 1577
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR04523
      Location:1500 → 2196
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:126 → 167
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:148 → 205
      LRR_8; Leucine rich repeat
      pfam15240
      Location:1151 → 1274
      Pro-rich; Proline-rich
      cl19219
      Location:488 → 585
      DUF342; Protein of unknown function (DUF342)

    15. XM_047422674.1 → XP_047278630.1  centriolin isoform X8

      UniProtKB/TrEMBL
      B2RP65

    16. XM_047422687.1 → XP_047278643.1  centriolin isoform X18

      UniProtKB/TrEMBL
      B2RP65

    17. XM_047422675.1 → XP_047278631.1  centriolin isoform X9

      UniProtKB/TrEMBL
      B2RP65

    18. XM_047422690.1 → XP_047278646.1  centriolin isoform X22

      UniProtKB/TrEMBL
      B2RP65

    19. XM_047422668.1 → XP_047278624.1  centriolin isoform X1

      UniProtKB/TrEMBL
      B2RP65

    20. XM_011518167.1 → XP_011516469.1  centriolin isoform X3

      See identical proteins and their annotated locations for XP_011516469.1

      UniProtKB/TrEMBL
      B2RP65
      Conserved Domains (9) summary
      COG4372
      Location:1320 → 1602
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:435 → 1119
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR04523
      Location:1525 → 2221
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:126 → 167
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:148 → 205
      LRR_8; Leucine rich repeat
      pfam15240
      Location:1176 → 1299
      Pro-rich; Proline-rich
      cl19219
      Location:513 → 610
      DUF342; Protein of unknown function (DUF342)

    21. XM_047422682.1 → XP_047278638.1  centriolin isoform X16

      UniProtKB/Swiss-Prot
      A2A2Y1, B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q7Z7A1, Q8TEP3, Q9Y489
      UniProtKB/TrEMBL
      B2RP65

    22. XM_047422686.1 → XP_047278642.1  centriolin isoform X13

      UniProtKB/TrEMBL
      B2RP65

    23. XM_047422679.1 → XP_047278635.1  centriolin isoform X12

      UniProtKB/TrEMBL
      B2RP65

    24. XM_047422672.1 → XP_047278628.1  centriolin isoform X6

      UniProtKB/TrEMBL
      B2RP65

    25. XM_047422685.1 → XP_047278641.1  centriolin isoform X8

      UniProtKB/TrEMBL
      B2RP65

    26. XM_047422689.1 → XP_047278645.1  centriolin isoform X20

      UniProtKB/TrEMBL
      B2RP65

    27. XM_047422684.1 → XP_047278640.1  centriolin isoform X18

      UniProtKB/TrEMBL
      B2RP65

    28. XM_047422676.1 → XP_047278632.1  centriolin isoform X9

      UniProtKB/TrEMBL
      B2RP65

    29. XM_047422680.1 → XP_047278636.1  centriolin isoform X14

      UniProtKB/TrEMBL
      B2RP65

    30. XM_047422691.1 → XP_047278647.1  centriolin isoform X23

    31. XM_047422692.1 → XP_047278648.1  centriolin isoform X24

    32. XM_011518172.4 → XP_011516474.1  centriolin isoform X25

      UniProtKB/TrEMBL
      Q5JVD1
      Conserved Domains (6) summary
      COG1196
      Location:435 → 1132
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam15240
      Location:1176 → 1299
      Pro-rich; Proline-rich
      pfam14580
      Location:130 → 279
      LRR_9; Leucine-rich repeat
      cl29113
      Location:76 → 181
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    33. XM_047422694.1 → XP_047278650.1  centriolin isoform X27

    34. XM_047422693.1 → XP_047278649.1  centriolin isoform X26

    35. XM_047422695.1 → XP_047278651.1  centriolin isoform X28

    36. XM_047422688.1 → XP_047278644.1  centriolin isoform X19

      UniProtKB/TrEMBL
      B2RP65

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      133271062..133373637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361817.1 → XP_054217792.1  centriolin isoform X1

      UniProtKB/TrEMBL
      B2RP65

    2. XM_054361823.1 → XP_054217798.1  centriolin isoform X5

      UniProtKB/TrEMBL
      B2RP65

    3. XM_054361819.1 → XP_054217794.1  centriolin isoform X2

      UniProtKB/TrEMBL
      B2RP65

    4. XM_054361826.1 → XP_054217801.1  centriolin isoform X7

      UniProtKB/TrEMBL
      B2RP65

    5. XM_054361831.1 → XP_054217806.1  centriolin isoform X11

      UniProtKB/TrEMBL
      B2RP65

    6. XM_054361838.1 → XP_054217813.1  centriolin isoform X17

      UniProtKB/TrEMBL
      B2RP65

    7. XM_054361830.1 → XP_054217805.1  centriolin isoform X10

      UniProtKB/TrEMBL
      B2RP65

    8. XM_054361822.1 → XP_054217797.1  centriolin isoform X4

      UniProtKB/TrEMBL
      B2RP65

    9. XM_054361836.1 → XP_054217811.1  centriolin isoform X15

      UniProtKB/TrEMBL
      B2RP65

    10. XM_054361820.1 → XP_054217795.1  centriolin isoform X3

      UniProtKB/TrEMBL
      B2RP65

    11. XM_054361834.1 → XP_054217809.1  centriolin isoform X13

      UniProtKB/TrEMBL
      B2RP65

    12. XM_054361845.1 → XP_054217820.1  centriolin isoform X21

      UniProtKB/TrEMBL
      B2RP65

    13. XM_054361833.1 → XP_054217808.1  centriolin isoform X12

      UniProtKB/TrEMBL
      B2RP65

    14. XM_054361824.1 → XP_054217799.1  centriolin isoform X6

      UniProtKB/TrEMBL
      B2RP65

    15. XM_054361827.1 → XP_054217802.1  centriolin isoform X8

      UniProtKB/TrEMBL
      B2RP65

    16. XM_054361842.1 → XP_054217817.1  centriolin isoform X18

      UniProtKB/TrEMBL
      B2RP65

    17. XM_054361828.1 → XP_054217803.1  centriolin isoform X9

      UniProtKB/TrEMBL
      B2RP65

    18. XM_054361846.1 → XP_054217821.1  centriolin isoform X22

      UniProtKB/TrEMBL
      B2RP65

    19. XM_054361818.1 → XP_054217793.1  centriolin isoform X1

      UniProtKB/TrEMBL
      B2RP65

    20. XM_054361821.1 → XP_054217796.1  centriolin isoform X3

      UniProtKB/TrEMBL
      B2RP65

    21. XM_054361837.1 → XP_054217812.1  centriolin isoform X16

      UniProtKB/Swiss-Prot
      A2A2Y1, B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q7Z7A1, Q8TEP3, Q9Y489
      UniProtKB/TrEMBL
      B2RP65

    22. XM_054361841.1 → XP_054217816.1  centriolin isoform X13

      UniProtKB/TrEMBL
      B2RP65

    23. XM_054361832.1 → XP_054217807.1  centriolin isoform X12

      UniProtKB/TrEMBL
      B2RP65

    24. XM_054361825.1 → XP_054217800.1  centriolin isoform X6

      UniProtKB/TrEMBL
      B2RP65

    25. XM_054361840.1 → XP_054217815.1  centriolin isoform X8

      UniProtKB/TrEMBL
      B2RP65

    26. XM_054361844.1 → XP_054217819.1  centriolin isoform X20

      UniProtKB/TrEMBL
      B2RP65

    27. XM_054361839.1 → XP_054217814.1  centriolin isoform X18

      UniProtKB/TrEMBL
      B2RP65

    28. XM_054361829.1 → XP_054217804.1  centriolin isoform X9

      UniProtKB/TrEMBL
      B2RP65

    29. XM_054361835.1 → XP_054217810.1  centriolin isoform X14

      UniProtKB/TrEMBL
      B2RP65

    30. XM_054361847.1 → XP_054217822.1  centriolin isoform X23

    31. XM_054361848.1 → XP_054217823.1  centriolin isoform X24

    32. XM_054361849.1 → XP_054217824.1  centriolin isoform X25

      UniProtKB/TrEMBL
      Q5JVD1

    33. XM_054361851.1 → XP_054217826.1  centriolin isoform X27

    34. XM_054361850.1 → XP_054217825.1  centriolin isoform X26

    35. XM_054361852.1 → XP_054217827.1  centriolin isoform X28

    36. XM_054361843.1 → XP_054217818.1  centriolin isoform X19

      UniProtKB/TrEMBL
      B2RP65
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7A1.2 GenPept UniProtKB/Swiss-Prot:Q7Z7A1

    Gene LinkOut

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