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    CROCCP2 CROCC pseudogene 2 [ Homo sapiens (human) ]

    Gene ID: 84809, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CROCCP2provided by HGNC
    Official Full Name
    CROCC pseudogene 2provided by HGNC
    Primary source
    HGNC:HGNC:28170
    See related
    Ensembl:ENSG00000291072 AllianceGenome:HGNC:28170
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CROCCL1
    Expression
    Ubiquitous expression in spleen (RPKM 16.1), duodenum (RPKM 15.2) and 25 other tissues See more
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    Genomic context

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    See CROCCP2 in Genome Data Viewer
    Location:
    1p36.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (16632279..16646683, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (16585910..16598560)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16944751..16957401, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Lys (CTT) 7-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16881397-16881897 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16890771-16891648 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16892527-16893404 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr1:16893405-16894282 Neighboring gene NBPF member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16902769-16903269 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16916551-16917050 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:16918378-16918567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16929815-16930315 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16933765-16934266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16934267-16934766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16939903-16940860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16945048-16945716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16945717-16946384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16946385-16947053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16950326-16950836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 334 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16963058-16963558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16964533-16965424 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:16970879-16971669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16971670-16972459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16973171-16973790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16974411-16975030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16975031-16975648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16976311-16976811 Neighboring gene macrophage stimulating 1 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16983417-16984225 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16992232-16993198 Neighboring gene FAM231A/C-like protein LOC102723383 Neighboring gene RNA, U1 small nuclear 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors. Van Heurck R, et al. Neuron, 2023 Jan 4. PMID 36334595, Free PMC Article
    2. Lineage-specific gene duplication and loss in human and great ape evolution. Fortna A, et al. PLoS Biol, 2004 Jul. PMID 15252450, Free PMC Article
    3. Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure. Michael ARM, et al. Nat Commun, 2024 Oct 2. PMID 39358380, Free PMC Article
    4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.
      Title: CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • ciliary rootlet coiled-coil, rootletin pseudogene 2
    • ciliary rootlet coiled-coil, rootletin-like 1

    Clone Names

    • MGC12760

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026752.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    2. NR_197601.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    3. NR_197602.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    4. NR_197603.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    5. NR_197604.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    6. NR_197605.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    7. NR_197606.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    8. NR_197607.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    9. NR_197608.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    10. NR_197609.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    11. NR_197610.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    12. NR_197611.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    13. NR_197612.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    14. NR_197613.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    15. NR_197614.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    16. NR_197615.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    17. NR_197616.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    18. NR_197617.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    19. NR_197618.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137798

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      16632279..16646683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      16618256..16631286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008485581.1 RNA Sequence

    2. XR_008485578.1 RNA Sequence

    3. XR_008485577.1 RNA Sequence

    4. XR_008485576.1 RNA Sequence

    5. XR_008485579.1 RNA Sequence

    6. XR_008485580.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791756.1 Reference GRCh38.p14 PATCHES

      Range
      993816..1006467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      16585910..16598560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      16245735..16260188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032723.2: Suppressed sequence

      Description
      NM_032723.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials