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    ZNF672 zinc finger protein 672 [ Homo sapiens (human) ]

    Gene ID: 79894, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF672provided by HGNC
    Official Full Name
    zinc finger protein 672provided by HGNC
    Primary source
    HGNC:HGNC:26179
    See related
    Ensembl:ENSG00000171161 AllianceGenome:HGNC:26179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 7.7), prostate (RPKM 7.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF672 in Genome Data Viewer
    Location:
    1q44
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248838224..248849517)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (248276707..248288000)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (249132423..249143716)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2049 Neighboring gene SH3 binding domain protein 5 like Neighboring gene Sharpr-MPRA regulatory region 9626 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:249114909-249116108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:249119908-249120459 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249120460-249121010 Neighboring gene microRNA 3124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249132357-249132858 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249132859-249133358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2882 Neighboring gene zinc finger protein 692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2885 Neighboring gene ZNF692 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2887

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22301

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 672

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024836.3 → NP_079112.1  zinc finger protein 672

      See identical proteins and their annotated locations for NP_079112.1

      Status: VALIDATED

      Source sequence(s)
      AI127478, BC007385, BC029310, HY030669
      Consensus CDS
      CCDS1638.1
      UniProtKB/Swiss-Prot
      Q499Z4, Q96H65, Q96IM3, Q9H6G5
      Related
      ENSP00000421915.1, ENST00000306562.8
      Conserved Domains (3) summary
      COG5048
      Location:12 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285 → 305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:325 → 350
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      248838224..248849517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430823.1 → XP_047286779.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q499Z4, Q96H65, Q96IM3, Q9H6G5

    2. XM_005270336.3 → XP_005270393.1  zinc finger protein 672 isoform X1

      See identical proteins and their annotated locations for XP_005270393.1

      UniProtKB/Swiss-Prot
      Q499Z4, Q96H65, Q96IM3, Q9H6G5
      Conserved Domains (3) summary
      COG5048
      Location:12 → 413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285 → 305
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:325 → 350
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      248276707..248288000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338802.1 → XP_054194777.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q499Z4, Q96H65, Q96IM3, Q9H6G5

    2. XM_054338803.1 → XP_054194778.1  zinc finger protein 672 isoform X1

      UniProtKB/Swiss-Prot
      Q499Z4, Q96H65, Q96IM3, Q9H6G5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499Z4.2 GenPept UniProtKB/Swiss-Prot:Q499Z4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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