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    FIRRM FIGNL1 interacting regulator of recombination and mitosis [ Homo sapiens (human) ]

    Gene ID: 55732, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FIRRMprovided by HGNC
    Official Full Name
    FIGNL1 interacting regulator of recombination and mitosisprovided by HGNC
    Primary source
    HGNC:HGNC:25565
    See related
    Ensembl:ENSG00000000460 AllianceGenome:HGNC:25565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLIP; Apolo1; MEICA1; C1orf112
    Summary
    Enables protein kinase binding activity. Involved in several processes, including chromosome segregation; interstrand cross-link repair; and regulation of protein kinase activity. Located in several cellular components, including kinetochore; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 5.7), lymph node (RPKM 3.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FIRRM in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169783837..169854080)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169139615..169209809)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169763871..169823221)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene selectin E Neighboring gene uncharacterized LOC101928628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169751147-169751648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2079 Neighboring gene methyltransferase 18, RPL3 N3(tau)-histidine Neighboring gene MPRA-validated peak450 silencer Neighboring gene RNA, 7SL, cytoplasmic 333, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2080 Neighboring gene SCY1 like pseudokinase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169862205-169862792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169862793-169863380 Neighboring gene VISTA enhancer hs1442 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:169914181-169914349 Neighboring gene kinesin associated protein 3 Neighboring gene RNA, 7SL, cytoplasmic 269, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair. Zhou Z, et al. Cell Rep, 2023 Aug 29. PMID 37515771
    2. [Remote results of health resort treatment of chronic prostatitis]. Fedorova NI. Vestn Dermatol Venerol, 1972 Feb. PMID 4260926
    3. Evolution, structure and emerging roles of C1ORF112 in DNA replication, DNA damage responses, and cancer. Edogbanya J, et al. Cell Mol Life Sci, 2021 May. PMID 33625522, Free PMC Article
    4. Pan-Cancer Analysis Identified C1ORF112 as a Potential Biomarker for Multiple Tumor Types. Chen J, et al. Front Mol Biosci, 2021. PMID 34490347, Free PMC Article
    5. High Expression of C1ORF112 Predicts a Poor Outcome: A Potential Target for the Treatment of Low-Grade Gliomas. Zhang Z, et al. Front Genet, 2021. PMID 34880897, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.
      Title: FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress.
    2. Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation.
      Title: Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation.
    3. Knockdown of C1orf112 by siRNA in HeLa cells significantly suppressed their growth.
      Title: GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10706, FLJ13470, MGC130018, MGC130019

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FIGNL1-interacting regulator of recombination and mitosis
    Names
    Fidgetin-like-1 interacting protein
    POLO1-associating protein
    associating protein with POLO1
    uncharacterized protein C1orf112

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320047.2 → NP_001306976.1  FIGNL1-interacting regulator of recombination and mitosis isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL031297, BC091516, DA770714, DC401980
      Consensus CDS
      CCDS1285.1
      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
      Related
      ENSP00000352276.4, ENST00000359326.9
      Conserved Domains (1) summary
      pfam14868
      Location:176 → 728
      DUF4487; Domain of unknown function (DUF4487)

    2. NM_001320048.2 → NP_001306977.1  FIGNL1-interacting regulator of recombination and mitosis isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK001568, AK303296, AL031297, BC091516
      UniProtKB/TrEMBL
      B4DGF2
      Conserved Domains (1) summary
      pfam14868
      Location:41 → 593
      DUF4487; Domain of unknown function (DUF4487)

    3. NM_001320050.2 → NP_001306979.1  FIGNL1-interacting regulator of recombination and mitosis isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK096493, BC011012, BC011445, CB159947, DC401980
      Consensus CDS
      CCDS81400.1
      UniProtKB/TrEMBL
      A0A1B0GV14
      Related
      ENSP00000490333.1, ENST00000496973.5

    4. NM_001320051.2 → NP_001306980.1  FIGNL1-interacting regulator of recombination and mitosis isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL354614, BC011445, BC091516, CB159947
      Consensus CDS
      CCDS81401.1
      UniProtKB/TrEMBL
      A0A1B0GUP7
      Related
      ENSP00000490194.1, ENST00000472795.5

    5. NM_001363739.2 → NP_001350668.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Consensus CDS
      CCDS86030.1
      Conserved Domains (1) summary
      pfam14868
      Location:1 → 405
      DUF4487; Domain of unknown function (DUF4487)

    6. NM_001366768.1 → NP_001353697.1  FIGNL1-interacting regulator of recombination and mitosis isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      UniProtKB/TrEMBL
      B4DGF2

    7. NM_001366769.1 → NP_001353698.1  FIGNL1-interacting regulator of recombination and mitosis isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      UniProtKB/TrEMBL
      B4DGF2
      Conserved Domains (1) summary
      pfam14868
      Location:234 → 786
      DUF4487; Domain of unknown function (DUF4487)

    8. NM_001366770.1 → NP_001353699.1  FIGNL1-interacting regulator of recombination and mitosis isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      UniProtKB/TrEMBL
      B4DGF2

    9. NM_001366771.1 → NP_001353700.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Consensus CDS
      CCDS86030.1
      Conserved Domains (1) summary
      pfam14868
      Location:1 → 405
      DUF4487; Domain of unknown function (DUF4487)

    10. NM_001366772.1 → NP_001353701.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Consensus CDS
      CCDS86030.1
      Related
      ENSP00000389257.3, ENST00000413811.3
      Conserved Domains (1) summary
      pfam14868
      Location:1 → 405
      DUF4487; Domain of unknown function (DUF4487)

    11. NM_001366773.1 → NP_001353702.1  FIGNL1-interacting regulator of recombination and mitosis isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Consensus CDS
      CCDS86030.1
      Conserved Domains (1) summary
      pfam14868
      Location:1 → 405
      DUF4487; Domain of unknown function (DUF4487)

    RNA

    1. NR_159440.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL021940, AL031297
      Related
      ENST00000459772.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      169783837..169854080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424760.1 → XP_047280716.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    2. XM_047424762.1 → XP_047280718.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    3. XM_047424751.1 → XP_047280707.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    4. XM_047424770.1 → XP_047280726.1  FIGNL1-interacting regulator of recombination and mitosis isoform X3

      UniProtKB/TrEMBL
      B4DGF2

    5. XM_047424752.1 → XP_047280708.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    6. XM_047424743.1 → XP_047280699.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2
      Related
      ENSP00000286031.6, ENST00000286031.10

    7. XM_047424759.1 → XP_047280715.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    8. XM_017001723.2 → XP_016857212.1  FIGNL1-interacting regulator of recombination and mitosis isoform X2

      UniProtKB/TrEMBL
      B4DGF2

    9. XM_047424771.1 → XP_047280727.1  FIGNL1-interacting regulator of recombination and mitosis isoform X4

    RNA

    1. XR_921872.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      169139615..169209809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337570.1 → XP_054193545.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    2. XM_054337571.1 → XP_054193546.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    3. XM_054337567.1 → XP_054193542.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    4. XM_054337568.1 → XP_054193543.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    5. XM_054337573.1 → XP_054193548.1  FIGNL1-interacting regulator of recombination and mitosis isoform X3

      UniProtKB/TrEMBL
      B4DGF2

    6. XM_054337569.1 → XP_054193544.1  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      UniProtKB/Swiss-Prot
      A6NFP1, B3KU42, Q3KNQ1, Q9H8L5, Q9NSG2, Q9NVJ0
      UniProtKB/TrEMBL
      B4DGF2

    7. XM_054337572.1 → XP_054193547.1  FIGNL1-interacting regulator of recombination and mitosis isoform X2

      UniProtKB/TrEMBL
      B4DGF2

    8. XM_054337574.1 → XP_054193549.1  FIGNL1-interacting regulator of recombination and mitosis isoform X4

    RNA

    1. XR_008486103.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018186.3: Suppressed sequence

      Description
      NM_018186.3: This RefSeq has been removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NSG2.1 GenPept UniProtKB/Swiss-Prot:Q9NSG2

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