TRMT1L tRNA methyltransferase 1 like [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRMT1Lprovided by HGNC
Official Full Name: tRNA methyltransferase 1 likeprovided by HGNC
Primary source: HGNC:HGNC:16782
See related: Ensembl:ENSG00000121486 MIM:611673; AllianceGenome:HGNC:16782
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRM1L; MST070; C1orf25; MSTP070; bG120K12.3
Summary: This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]
Expression: Broad expression in testis (RPKM 9.7), kidney (RPKM 3.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q25.3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (185118101..185157537, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (184475011..184514447, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (185087233..185126230, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Includes the identification of the C1orf25 gene.
Title: Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.
Functional characterization of the mouse C1orf25 ortholog and comparison to the human protein.
Title: The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Interaction of HIV-1 Gag with tRNA methyltransferase 1 homolog (S. cerevisiae)-like (TRMT1L) is identified in a series of six affinity purification/mass spectrometry screens	PubMed
Rev	rev	HIV-1 Rev interacting protein, TRMT1-like protein, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46035 (e-PCR)
- UniSTS:84095

SHGC-76037 (e-PCR)
- UniSTS:4271

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tRNA (guanine) methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA N2-guanine methylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TRMT1-like protein

Names: TRM1 tRNA methyltransferase 1-like; TRM1-like protein; tRNA methyltransferase 1 homolog-like

NP_001189352.1

EC 2.1.1.-

NP_112196.3

EC 2.1.1.-

XP_047287247.1

EC 2.1.1.-

XP_047287248.1

EC 2.1.1.-

XP_054194899.1

EC 2.1.1.-

XP_054194900.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001202423.2 → NP_001189352.1 TRMT1-like protein isoform 2

See identical proteins and their annotated locations for NP_001189352.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AF163261, AK074993, AK226103, AK302166, BU198525, DC398320

UniProtKB/TrEMBL

B4DXX1

Conserved Domains (1) summary

cl17173
Location:95 → 536

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_030934.5 → NP_112196.3 TRMT1-like protein isoform 1

See identical proteins and their annotated locations for NP_112196.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF288399, AK226103, BC045535, DB093548

Consensus CDS

CCDS1366.1

UniProtKB/Swiss-Prot

Q5TEN0, Q6ZMX0, Q7Z2T5, Q8IWH5, Q8NC68, Q9BZQ1

UniProtKB/TrEMBL

B2R713

Related

ENSP00000356476.5, ENST00000367506.10

Conserved Domains (1) summary

cl17173
Location:251 → 692

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

185118101..185157537 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047431291.1 → XP_047287247.1 TRMT1-like protein isoform X1

UniProtKB/TrEMBL

B4DXX1
XM_047431292.1 → XP_047287248.1 TRMT1-like protein isoform X1

UniProtKB/TrEMBL

B4DXX1

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

184475011..184514447 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054338924.1 → XP_054194899.1 TRMT1-like protein isoform X1

UniProtKB/TrEMBL

B4DXX1
XM_054338925.1 → XP_054194900.1 TRMT1-like protein isoform X1

UniProtKB/TrEMBL

B4DXX1