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    CKLF chemokine like factor [ Homo sapiens (human) ]

    Gene ID: 51192, updated on 10-Dec-2024

    Summary

    Official Symbol
    CKLFprovided by HGNC
    Official Full Name
    chemokine like factorprovided by HGNC
    Primary source
    HGNC:HGNC:13253
    See related
    Ensembl:ENSG00000217555 MIM:616074; AllianceGenome:HGNC:13253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C32; CKLF1; CKLF2; CKLF3; CKLF4; UCK-1; HSPC224
    Summary
    The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in appendix (RPKM 18.6), testis (RPKM 17.1) and 24 other tissues See more
    Orthologs
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    Genomic context

    See CKLF in Genome Data Viewer
    Location:
    16q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (66552563..66566287)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (72346858..72360582)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66586466..66600190)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene brain expressed associated with NEDD4 1 Neighboring gene uncharacterized LOC124903698 Neighboring gene BEAN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66510981-66511522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66512063-66512603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66513685-66514224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66518060-66519040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66521703-66522203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66543229-66544204 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66545181-66546156 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:66546157-66547132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:66553931-66554431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10940 Neighboring gene thymidine kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10941 Neighboring gene CKLF-CMTM1 readthrough Neighboring gene CKLF like MARVEL transmembrane domain containing 1 Neighboring gene CKLF like MARVEL transmembrane domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of chemokine-like factor (CKLF; HSPC224) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
    Knockdown of chemokine-like factor (CKLF) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Readthrough CKLF-CMTM1

    Readthrough gene: CKLF-CMTM1, Included gene: CMTM1

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular region PubMed 
    located_in extracellular space  
    located_in membrane PubMed 
    is_active_in membrane  
    located_in membrane PubMed 

    General protein information

    Preferred Names
    chemokine-like factor
    Names
    chemokine-like factor 1
    chemokine-like factor 2
    chemokine-like factor 3
    chemokine-like factor 4
    transmembrane proteolipid

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040138.3 → NP_001035228.1  chemokine-like factor isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the coding region and 3' UTR, compared to variant 1. The encoded isoform (e) is shorter and contains a unique C-terminus, compared to isoform a.
      Source sequence(s)
      BU189908, DA113473, DA804889
      Consensus CDS
      CCDS45502.1
      UniProtKB/TrEMBL
      I7GPS8
      Related
      ENSP00000416678.2, ENST00000417030.2
    2. NM_016326.3 → NP_057410.1  chemokine-like factor isoform c

      See identical proteins and their annotated locations for NP_057410.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two an in-frame exons in the coding region, compared to variant 1. It encodes a shorter isoform (c), also known as an isoform CKL3.
      Source sequence(s)
      AF135381, BU189908, DA113473
      Consensus CDS
      CCDS10806.1
      UniProtKB/Swiss-Prot
      Q9UBR5
      Related
      ENSP00000355417.4, ENST00000362093.4
    3. NM_016951.4 → NP_058647.1  chemokine-like factor isoform a

      See identical proteins and their annotated locations for NP_058647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (a), also known as an isoform CKLF2.
      Source sequence(s)
      AF135380
      Consensus CDS
      CCDS10807.1
      UniProtKB/Swiss-Prot
      C9JE38, Q9UBR5, Q9UHM7, Q9UHN8, Q9UI41
      UniProtKB/TrEMBL
      I7GPS8
      Related
      ENSP00000264001.5, ENST00000264001.9
      Conserved Domains (1) summary
      pfam01284
      Location:26 → 98
      MARVEL; Membrane-associating domain
    4. NM_181640.2 → NP_857591.1  chemokine-like factor isoform b

      See identical proteins and their annotated locations for NP_857591.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), also known as an isoform CKLF1.
      Source sequence(s)
      AF096895, BU189908, DA113473
      Consensus CDS
      CCDS10808.1
      UniProtKB/TrEMBL
      Q5BJH6
      Related
      ENSP00000264003.4, ENST00000351137.8
    5. NM_181641.2 → NP_857592.1  chemokine-like factor isoform d

      See identical proteins and their annotated locations for NP_857592.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (d), also known as an isoform CKLF4.
      Source sequence(s)
      AF145216, BU189908, DA113473
      Consensus CDS
      CCDS10809.1
      UniProtKB/Swiss-Prot
      Q9UBR5
      Related
      ENSP00000290771.4, ENST00000345436.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      66552563..66566287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      72346858..72360582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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