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    WNT6 Wnt family member 6 [ Homo sapiens (human) ]

    Gene ID: 7475, updated on 10-Dec-2024

    Summary

    Official Symbol
    WNT6provided by HGNC
    Official Full Name
    Wnt family member 6provided by HGNC
    Primary source
    HGNC:HGNC:12785
    See related
    Ensembl:ENSG00000115596 MIM:604663; AllianceGenome:HGNC:12785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in placenta (RPKM 1.4), prostate (RPKM 1.1) and 13 other tissues See more
    Orthologs
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    Genomic context

    See WNT6 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218859805..218874233)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219348208..219362636)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219724528..219738955)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:219687585-219688784 Neighboring gene microRNA 9500 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 3 Neighboring gene ribosomal protein L23a pseudogene 31 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12327 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219736377-219737323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12330 Neighboring gene Wnt family member 10A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17131 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219757282-219757864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17134 Neighboring gene uncharacterized LOC105373882 Neighboring gene Sharpr-MPRA regulatory region 8081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12337 Neighboring gene long intergenic non-protein coding RNA 1494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17136 Neighboring gene uncharacterized LOC124906119 Neighboring gene RNA, U6 small nuclear 642, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity  
    enables frizzled binding  
    Process Evidence Code Pubs
    involved_in axis specification  
    involved_in branching involved in ureteric bud morphogenesis  
    involved_in canonical Wnt signaling pathway  
    involved_in cell fate commitment  
    involved_in cellular response to retinoic acid  
    involved_in cornea development in camera-type eye PubMed 
    involved_in epithelial-mesenchymal cell signaling  
    involved_in nephron tubule formation  
    involved_in neuron differentiation  
    involved_in neuron differentiation  
    involved_in odontogenesis of dentin-containing tooth PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of tooth mineralization PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen  
    located_in cell surface  
    located_in endocytic vesicle membrane  
    located_in endoplasmic reticulum lumen  
    located_in extracellular exosome  
    located_in extracellular matrix  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in plasma membrane  

    General protein information

    Preferred Names
    protein Wnt-6
    Names
    wingless-type MMTV integration site family, member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046932.1 RefSeqGene

      Range
      4983..19411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006522.4NP_006513.1  protein Wnt-6 precursor

      See identical proteins and their annotated locations for NP_006513.1

      Status: REVIEWED

      Source sequence(s)
      AB059570, AC009974, AC073128, AK075522, BC004329, CB960823
      Consensus CDS
      CCDS2425.1
      UniProtKB/Swiss-Prot
      Q9H1J6, Q9H238, Q9Y6F9
      UniProtKB/TrEMBL
      Q8N2E5
      Related
      ENSP00000233948.3, ENST00000233948.4
      Conserved Domains (1) summary
      pfam00110
      Location:47364
      wnt; wnt family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      218859805..218874233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      219348208..219362636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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