FPR1 formyl peptide receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FPR1provided by HGNC
Official Full Name: formyl peptide receptor 1provided by HGNC
Primary source: HGNC:HGNC:3826
See related: Ensembl:ENSG00000171051 MIM:136537; AllianceGenome:HGNC:3826
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FPR; FMLP
Summary: This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
Expression: Biased expression in appendix (RPKM 94.6), bone marrow (RPKM 64.2) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.41

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (51745172..51751878, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (54832367..54839072, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (52248425..52255131, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FPR1: A critical gatekeeper of the heart and brain.
Title: FPR1: A critical gatekeeper of the heart and brain.
Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer.
Title: Rs867228 in FPR1 accelerates the manifestation of luminal B breast cancer.
Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
Title: Formyl peptide receptor 2 is an emerging modulator of inflammation in the liver.
Amyloid beta and its naturally occurring N-terminal variants are potent activators of human and mouse formyl peptide receptor 1.
Title: Amyloid beta and its naturally occurring N-terminal variants are potent activators of human and mouse formyl peptide receptor 1.
Agonist concentration-dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions.
Title: Agonist concentration-dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions.
Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
Title: Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.
Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling.
Title: Breast cancer metastasis to brain results in recruitment and activation of microglia through annexin-A1/formyl peptide receptor signaling.
The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
Title: The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase Activity.
Evaluation of the Genetic Association and Methylation of Immune Response Pathway Genes with the Risk of Chronic Periodontitis in the Uighur Population.
Title: Evaluation of the Genetic Association and Methylation of Immune Response Pathway Genes with the Risk of Chronic Periodontitis in the Uighur Population.
Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo.
Title: Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Interaction of HIV-1 gp120 with CD4 is sufficient to trigger a marked reduction in C5a Receptor and a modest reduction in FMLP Receptor on monocytes	PubMed
	env	N-formyl-methionyl-leucylphenyl-alanine binding to formyl peptide receptor (FPR) results in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1 gp120-mediated fusion and infection of cells expressing CD4, CCR5, and FPR	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH69009 (e-PCR)
- UniSTS:81170

D19S1083 (e-PCR)
- UniSTS:45120

RH17955 (e-PCR)
- UniSTS:82329

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables N-formyl peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-formyl peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables RAGE receptor binding	IEA Inferred from Electronic Annotation more info
enables complement receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in nitric oxide mediated signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule membrane	TAS Traceable Author Statement more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in ficolin-1-rich granule membrane	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: fMet-Leu-Phe receptor

Names: N-formylpeptide chemoattractant receptor; fMLP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023426.1 RefSeqGene

Range

5001..11128

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_146

mRNA and Protein(s)

NM_001193306.2 → NP_001180235.1 fMet-Leu-Phe receptor

See identical proteins and their annotated locations for NP_001180235.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC018755

Consensus CDS

CCDS12839.1

UniProtKB/Swiss-Prot

P21462, Q14939, Q7Z6A4, Q86U52, Q9NS48

UniProtKB/TrEMBL

B2RC44

Related

ENSP00000471493.1, ENST00000595042.5

Conserved Domains (2) summary

cd14964
Location:29 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_002029.4 → NP_002020.1 fMet-Leu-Phe receptor

See identical proteins and their annotated locations for NP_002020.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC005315, BQ016000, M60627

Consensus CDS

CCDS12839.1

UniProtKB/Swiss-Prot

P21462, Q14939, Q7Z6A4, Q86U52, Q9NS48

UniProtKB/TrEMBL

B2RC44

Related

ENSP00000302707.3, ENST00000304748.5

Conserved Domains (2) summary

cd14964
Location:29 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily