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    EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 8637, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EIF4EBP3provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:3290
    See related
    Ensembl:ENSG00000243056 MIM:603483; AllianceGenome:HGNC:3290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    4EBP3; 4E-BP3
    Summary
    This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 14.1), kidney (RPKM 13.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF4EBP3 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (140547662..140549576)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (141073092..141075006)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139927247..139929161)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ANKHD1 divergent transcript Neighboring gene ANKHD1-EIF4EBP3 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23272 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:139786226-139786726 Neighboring gene RNA, U4 small nuclear 14, pseudogene Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:139805430-139805930 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:139805931-139806431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139808054-139808563 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139812829-139813329 Neighboring gene uncharacterized LOC124901194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139926194-139926902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139926903-139927609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139927610-139928317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139936291-139937112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23276 Neighboring gene steroid receptor RNA activator 1 Neighboring gene microRNA 6831 Neighboring gene amyloid beta precursor protein binding family B member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer. Zhai S, et al. Gastric Cancer, 2020 May. PMID 31853750
    2. MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells. Lv KT, et al. Int J Med Sci, 2018. PMID 29333098, Free PMC Article
    3. Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. Tsukumo Y, et al. Nat Commun, 2016 Jun 20. PMID 27319316, Free PMC Article
    4. Localisation and regulation of the eIF4E-binding protein 4E-BP3. Kleijn M, et al. FEBS Lett, 2002 Dec 18. PMID 12482586
    5. Prognostic significance of expression of eukaryotic initiation factor 4E and 4E binding protein 1 in patients with pathological stage I invasive lung adenocarcinoma. Seki N, et al. Lung Cancer, 2010 Dec. PMID 20621385

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/beta-catenin in gastric cancer.
      Title: eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer.
    2. Role of the eIF4EBP3 gene in miR-22-3p-mediated cervical squamous carcinoma cell growth
      Title: MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells.
    3. The data reveal that 4E-BP3 expression is controlled by the transcription factor TFE3 through a cis-regulatory element in the EIF4EBP3 gene promoter.
      Title: Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.
    4. 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2
      Title: 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.
    5. potential prognostic factor for survival in patients with lung adenocarcinoma
      Title: Prognostic significance of expression of eukaryotic initiation factor 4E and 4E binding protein 1 in patients with pathological stage I invasive lung adenocarcinoma.
    6. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway.
    7. 4E-BP3 is associated with eIF4E in the cell nucleus and cytoplasm
      Title: Localisation and regulation of the eIF4E-binding protein 4E-BP3.
    8. there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK
      Title: Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.
    9. PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin
      Title: Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough ANKHD1-EIF4EBP3

    Readthrough gene: ANKHD1-EIF4EBP3, Included gene: ANKHD1

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation repressor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translational initiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 3
    Names
    eIF4E-binding protein 3
    eukaryotic initiation factor 4E-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003732.3 → NP_003723.1  eukaryotic translation initiation factor 4E-binding protein 3

      See identical proteins and their annotated locations for NP_003723.1

      Status: REVIEWED

      Source sequence(s)
      AC011399, AF038869, BC010881
      Consensus CDS
      CCDS4226.1
      UniProtKB/Swiss-Prot
      O60516
      Related
      ENSP00000308472.2, ENST00000310331.3
      Conserved Domains (1) summary
      pfam05456
      Location:5 → 100
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      140547662..140549576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      141073092..141075006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60516.1 GenPept UniProtKB/Swiss-Prot:O60516

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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