Pax8 paired box 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pax8provided by RGD
Official Full Name: paired box 8provided by RGD
Primary source: RGD:620434
See related: EnsemblRapid:ENSRNOG00000026203 AllianceGenome:RGD:620434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of DNA-templated transcription and sulfur compound metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Orthologous to human PAX8 (paired box 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 165.1) and Uterus (RPKM 18.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (27584000..27641094, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (7185721..7242363, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (1527316..1586019, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Critical Balance Between PAX8 and the Hippo Mediator TAZ Determines Sodium/Iodide Symporter Expression and Function.
Title: A Critical Balance Between PAX8 and the Hippo Mediator TAZ Determines Sodium/Iodide Symporter Expression and Function.
PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis.
Title: PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis.
Pax8 controls apical-basal follicular polarization and follicle formation through Cdh16.
Title: Pax8 controls thyroid follicular polarity through cadherin-16.
the novel interplay between PAX8 and Neuropilin-2
Title: Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells.
The 5'-flanking region of the Wnt4 gene is responsive to Pax8. Pax8 modulates the expression of Wnt4 in thyroid cells.
Title: Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells.
Pax8 is required for the survival of differentiated epithelial cells and its expression levels are able to modulate the proliferation rate of such cells.
Title: Pax8 has a critical role in epithelial cell survival and proliferation.
Distal regulation by Pax8 is supported by the interaction with chromatin remodeling factors such as CTCF and Sp1.
Title: Genome-wide analysis of Pax8 binding provides new insights into thyroid functions.
Transcriptome analysis highlighted that Pax8 is a key molecule for thyroid morphogenesis and differentiation
Title: Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis.
An unusual negative cross talk between Ras oncogene and the cyclic AMP pathway induces inactivation of the transcription factor Pax8.
Title: Oncogenic ras blocks the cAMP pathway and dedifferentiates thyroid cells via an impairment of pax8 transcriptional activity.
thyrotropin-dependent thyroglobulin gene expression is stimulated by bacterial lipopolysaccharide at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8
Title: Bacterial lipopolysaccharide stimulates the thyrotropin-dependent thyroglobulin gene expression at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

Pax8 (e-PCR), detects polymorphism
- UniSTS:536833

D11Bir2 (e-PCR), detects polymorphism
- UniSTS:141710

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin stimulus	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney epithelium development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mesonephric tubule development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in metanephric comma-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in metanephric distal convoluted tubule development	ISO Inferred from Sequence Orthology more info
involved_in metanephric distal convoluted tubule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric epithelium development	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron tubule formation	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron tubule formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process involved in metanephric collecting duct development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process involved in metanephric collecting duct development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process involved in metanephric nephron tubule development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process involved in metanephric nephron tubule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in otic vesicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metanephric DCT cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric DCT cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thyroid hormone generation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pronephric field specification	ISO Inferred from Sequence Orthology more info
involved_in pronephric field specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in pronephros development	ISO Inferred from Sequence Orthology more info
involved_in pronephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of metanephric nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of metanephric nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of thyroid-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of thyroid-stimulating hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfur compound metabolic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in thyroid gland development	ISS Inferred from Sequence or Structural Similarity more info
involved_in urogenital system development	ISO Inferred from Sequence Orthology more info
involved_in urogenital system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular septum development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paired box protein Pax-8

Names: Pax-8 protein; paired box gene 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429514.1 → NP_001416443.1 paired box protein Pax-8 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2JY90
NM_031141.2 → NP_112403.2 paired box protein Pax-8 isoform 1

See identical proteins and their annotated locations for NP_112403.2

Status: PROVISIONAL

Source sequence(s)

BC081779

UniProtKB/Swiss-Prot

P51974, Q66HM8

UniProtKB/TrEMBL

A0A0G2JY90, A6JSY7

Related

ENSRNOP00000033966.7, ENSRNOT00000031058.8

Conserved Domains (2) summary

smart00351
Location:9 → 133

PAX; Paired Box domain

pfam12403
Location:344 → 455

Pax2_C; Paired-box protein 2 C terminal