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    NIPA2 NIPA magnesium transporter 2 [ Homo sapiens (human) ]

    Gene ID: 81614, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NIPA2provided by HGNC
    Official Full Name
    NIPA magnesium transporter 2provided by HGNC
    Primary source
    HGNC:HGNC:17044
    See related
    Ensembl:ENSG00000140157 MIM:608146; AllianceGenome:HGNC:17044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLC57A2
    Summary
    This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21.[provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in colon (RPKM 14.5), appendix (RPKM 13.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NIPA2 in Genome Data Viewer
    Location:
    15q11.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (22838666..22868384)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (20510413..20540236)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (23004684..23034402, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC283683 Neighboring gene Sharpr-MPRA regulatory region 3977 Neighboring gene golgin subfamily A member 6-like protein 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:23086519-23086752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:23080143-23080643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9155 Neighboring gene NIPA magnesium transporter 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:23045427-23046179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22999149-22999824 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:22990202-22991401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22981163-22981662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22980661-22981162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9159 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22925256-22925940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22905531-22906030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22896003-22896502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22895501-22896002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22893404-22894371 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22892435-22893403 Neighboring gene tubulin gamma complex component 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22859095-22860005 Neighboring gene NANOG hESC enhancer GRCh37_chr15:22803142-22803643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22798435-22798945 Neighboring gene engulfment and cell motility 2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NIPA2 regulates osteoblast function via its effect on apoptosis pathways in type 2 diabetes osteoporosis. Zhao W, et al. Biochem Biophys Res Commun, 2019 Jun 11. PMID 31003774
    2. Functional study of NIPA2 mutations identified from the patients with childhood absence epilepsy. Xie H, et al. PLoS One, 2014. PMID 25347071, Free PMC Article
    3. NIPA2 located in 15q11.2 is mutated in patients with childhood absence epilepsy. Jiang Y, et al. Hum Genet, 2012 Jul. PMID 22367439
    4. Molecular identification of ancient and modern mammalian magnesium transporters. Quamme GA. Am J Physiol Cell Physiol, 2010 Mar. PMID 19940067
    5. Nine patients with a microdeletion 15q11.2 between breakpoints 1 and 2 of the Prader-Willi critical region, possibly associated with behavioural disturbances. Doornbos M, et al. Eur J Med Genet, 2009 Mar-Jun. PMID 19328872

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AGEs dose-dependently down-regulated the expression of NIPA2 in osteoblasts. NIPA2 also regulated osteoblast apoptosis by affecting the intracellular magnesium level and further affecting the osteogenic capacity of osteoblasts.
      Title: NIPA2 regulates osteoblast function via its effect on apoptosis pathways in type 2 diabetes osteoporosis.
    2. This study primarily reveals that a selective magnesium transporter NIPA2 may play a role in the pathogenesis of CAE.
      Title: Functional study of NIPA2 mutations identified from the patients with childhood absence epilepsy.
    3. mutations in NIPA2 gene were associated with childhood absence epilepsy (CAE), which indicated that the haploinsufficiency of NIPA2 might be a candidate mechanism underlying the IGE/CAE phenotypes caused by 15q11.2 microdeletions or rare mutations in NIPA2
      Title: NIPA2 located in 15q11.2 is mutated in patients with childhood absence epilepsy.
    4. located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes
      Title: Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.
    5. quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales
      Title: Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome.
    6. Altered mRNA expression is associated with prostate cancer recurrence.
      Title: Gene expression profiling predicts clinical outcome of prostate cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-04-04)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-04-04)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5466

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    magnesium transporter NIPA2
    Names
    non imprinted in Prader-Willi/Angelman syndrome 2
    non-imprinted in Prader-Willi/Angelman syndrome region protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021303.1 RefSeqGene

      Range
      5026..34744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001008860.3 → NP_001008860.1  magnesium transporter NIPA2 isoform a

      See identical proteins and their annotated locations for NP_001008860.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
      Source sequence(s)
      AC011767, BK001120, DA082125, R56244
      Consensus CDS
      CCDS73693.1
      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Related
      ENSP00000501489.1, ENST00000674477.1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    2. NM_001008892.3 → NP_001008892.1  magnesium transporter NIPA2 isoform a

      See identical proteins and their annotated locations for NP_001008892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
      Source sequence(s)
      AC011767, BC011775, DA082125, R56244, U90904
      Consensus CDS
      CCDS73693.1
      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Related
      ENSP00000381095.3, ENST00000398013.7
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    3. NM_001008894.3 → NP_001008894.1  magnesium transporter NIPA2 isoform b

      See identical proteins and their annotated locations for NP_001008894.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 4 and 6 encode the same isoform (b).
      Source sequence(s)
      AC011767, AK300843, DA082125, R56244, U90904
      Consensus CDS
      CCDS73694.1
      UniProtKB/Swiss-Prot
      Q8N8Q9
      Related
      ENSP00000437746.2, ENST00000539711.2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    4. NM_001184888.2 → NP_001171817.1  magnesium transporter NIPA2 isoform b

      See identical proteins and their annotated locations for NP_001171817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 4 and 6 encode the same isoform (b).
      Source sequence(s)
      AC011767, AK313584, R56244, U90904
      Consensus CDS
      CCDS73694.1
      UniProtKB/Swiss-Prot
      Q8N8Q9
      Related
      ENSP00000352762.4, ENST00000359727.8
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    5. NM_001184889.2 → NP_001171818.1  magnesium transporter NIPA2 isoform a

      See identical proteins and their annotated locations for NP_001171818.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
      Source sequence(s)
      AC011767, AY732242, DA082125, R56244, U90904
      Consensus CDS
      CCDS73693.1
      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    6. NM_030922.7 → NP_112184.4  magnesium transporter NIPA2 isoform a

      See identical proteins and their annotated locations for NP_112184.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 3 and 4 encode the same isoform (a).
      Source sequence(s)
      AC011767, BC000957, BM544162, DA082125, R56244, U90904
      Consensus CDS
      CCDS73693.1
      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Related
      ENSP00000337618.3, ENST00000337451.8
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      22838666..22868384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022651.3 → XP_016878140.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    2. XM_017022645.2 → XP_016878134.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    3. XM_047433150.1 → XP_047289106.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    4. XM_047433152.1 → XP_047289108.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    5. XM_011543877.3 → XP_011542179.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_011542179.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    6. XM_047433158.1 → XP_047289114.1  magnesium transporter NIPA2 isoform X2

    7. XM_017022649.3 → XP_016878138.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    8. XM_047433162.1 → XP_047289118.1  magnesium transporter NIPA2 isoform X2

    9. XM_011543878.4 → XP_011542180.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_011542180.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    10. XM_005272546.4 → XP_005272603.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_005272603.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    11. XM_006720367.2 → XP_006720430.1  magnesium transporter NIPA2 isoform X2

      See identical proteins and their annotated locations for XP_006720430.1

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    12. XM_011543880.4 → XP_011542182.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_011542182.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    13. XM_017022660.2 → XP_016878149.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    14. XM_005272550.4 → XP_005272607.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_005272607.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    15. XM_005272552.5 → XP_005272609.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_005272609.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Related
      ENSP00000501373.1, ENST00000674330.1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    16. XM_017022662.2 → XP_016878151.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    17. XM_017022648.2 → XP_016878137.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    18. XM_047433155.1 → XP_047289111.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    19. XM_017022647.2 → XP_016878136.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    20. XM_047433160.1 → XP_047289116.1  magnesium transporter NIPA2 isoform X2

    21. XM_017022652.3 → XP_016878141.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    22. XM_047433151.1 → XP_047289107.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    23. XM_005272547.5 → XP_005272604.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_005272604.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    24. XM_017022656.2 → XP_016878145.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    25. XM_047433153.1 → XP_047289109.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    26. XM_047433163.1 → XP_047289119.1  magnesium transporter NIPA2 isoform X2

    27. XM_005272553.6 → XP_005272610.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_005272610.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    28. XM_017022663.2 → XP_016878152.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    29. XM_047433154.1 → XP_047289110.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    30. XM_047433156.1 → XP_047289112.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    31. XM_017022646.2 → XP_016878135.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    32. XM_047433159.1 → XP_047289115.1  magnesium transporter NIPA2 isoform X2

    33. XM_017022653.3 → XP_016878142.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    34. XM_006720364.3 → XP_006720427.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_006720427.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    35. XM_017022657.2 → XP_016878146.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    36. XM_011543879.4 → XP_011542181.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_011542181.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    37. XM_017022659.2 → XP_016878148.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    38. XM_017022650.3 → XP_016878139.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    39. XM_017022655.2 → XP_016878144.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Related
      ENSP00000381096.3, ENST00000398014.7
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    40. XM_017022661.2 → XP_016878150.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    41. XM_017022654.3 → XP_016878143.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    42. XM_005272548.4 → XP_005272605.1  magnesium transporter NIPA2 isoform X1

      See identical proteins and their annotated locations for XP_005272605.1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
      Related
      ENSP00000501408.1, ENST00000674173.1
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 302
      Mg_trans_NIPA; Magnesium transporter NIPA

    43. XM_017022658.2 → XP_016878147.1  magnesium transporter NIPA2 isoform X2

      UniProtKB/Swiss-Prot
      Q8N8Q9
      Conserved Domains (1) summary
      pfam05653
      Location:8 → 283
      Mg_trans_NIPA; Magnesium transporter NIPA

    44. XM_047433157.1 → XP_047289113.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    45. XM_047433161.1 → XP_047289117.1  magnesium transporter NIPA2 isoform X2

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      3732709..3762464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332624.1 → XP_054188599.1  magnesium transporter NIPA2 isoform X2

    2. XM_054332597.1 → XP_054188572.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    3. XM_054332589.1 → XP_054188564.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    4. XM_054332583.1 → XP_054188558.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    5. XM_054332603.1 → XP_054188578.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    6. XM_054332609.1 → XP_054188584.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    7. XM_054332619.1 → XP_054188594.1  magnesium transporter NIPA2 isoform X2

    8. XM_054332612.1 → XP_054188587.1  magnesium transporter NIPA2 isoform X2

    9. XM_054332620.1 → XP_054188595.1  magnesium transporter NIPA2 isoform X2

    10. XM_054332617.1 → XP_054188592.1  magnesium transporter NIPA2 isoform X2

    11. XM_054332614.1 → XP_054188589.1  magnesium transporter NIPA2 isoform X2

    12. XM_054332623.1 → XP_054188598.1  magnesium transporter NIPA2 isoform X2

    13. XM_054332586.1 → XP_054188561.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    14. XM_054332585.1 → XP_054188560.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    15. XM_054332596.1 → XP_054188571.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    16. XM_054332595.1 → XP_054188570.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    17. XM_054332608.1 → XP_054188583.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    18. XM_054332592.1 → XP_054188567.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    19. XM_054332591.1 → XP_054188566.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    20. XM_054332607.1 → XP_054188582.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    21. XM_054332602.1 → XP_054188577.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    22. XM_054332601.1 → XP_054188576.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    23. XM_054332584.1 → XP_054188559.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    24. XM_054332590.1 → XP_054188565.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    25. XM_054332600.1 → XP_054188575.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    26. XM_054332604.1 → XP_054188579.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    27. XM_054332594.1 → XP_054188569.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    28. XM_054332611.1 → XP_054188586.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    29. XM_054332606.1 → XP_054188581.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    30. XM_054332605.1 → XP_054188580.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    31. XM_054332588.1 → XP_054188563.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    32. XM_054332616.1 → XP_054188591.1  magnesium transporter NIPA2 isoform X2

    33. XM_054332587.1 → XP_054188562.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    34. XM_054332615.1 → XP_054188590.1  magnesium transporter NIPA2 isoform X2

    35. XM_054332598.1 → XP_054188573.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    36. XM_054332599.1 → XP_054188574.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    37. XM_054332621.1 → XP_054188596.1  magnesium transporter NIPA2 isoform X2

    38. XM_054332613.1 → XP_054188588.1  magnesium transporter NIPA2 isoform X2

    39. XM_054332622.1 → XP_054188597.1  magnesium transporter NIPA2 isoform X2

    40. XM_054332610.1 → XP_054188585.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    41. XM_054332593.1 → XP_054188568.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    42. XM_054332618.1 → XP_054188593.1  magnesium transporter NIPA2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      20510413..20540236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378962.1 → XP_054234937.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    2. XM_054378940.1 → XP_054234915.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    3. XM_054378950.1 → XP_054234925.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    4. XM_054378978.1 → XP_054234953.1  magnesium transporter NIPA2 isoform X2

    5. XM_054378942.1 → XP_054234917.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    6. XM_054378943.1 → XP_054234918.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    7. XM_054378959.1 → XP_054234934.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    8. XM_054378939.1 → XP_054234914.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    9. XM_054378951.1 → XP_054234926.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    10. XM_054378964.1 → XP_054234939.1  magnesium transporter NIPA2 isoform X2

    11. XM_054378958.1 → XP_054234933.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    12. XM_054378967.1 → XP_054234942.1  magnesium transporter NIPA2 isoform X2

    13. XM_054378972.1 → XP_054234947.1  magnesium transporter NIPA2 isoform X2

    14. XM_054378973.1 → XP_054234948.1  magnesium transporter NIPA2 isoform X2

    15. XM_054378970.1 → XP_054234945.1  magnesium transporter NIPA2 isoform X2

    16. XM_054378977.1 → XP_054234952.1  magnesium transporter NIPA2 isoform X2

    17. XM_054378969.1 → XP_054234944.1  magnesium transporter NIPA2 isoform X2

    18. XM_054378966.1 → XP_054234941.1  magnesium transporter NIPA2 isoform X2

    19. XM_054378976.1 → XP_054234951.1  magnesium transporter NIPA2 isoform X2

    20. XM_054378954.1 → XP_054234929.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    21. XM_054378953.1 → XP_054234928.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    22. XM_054378941.1 → XP_054234916.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    23. XM_054378947.1 → XP_054234922.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    24. XM_054378961.1 → XP_054234936.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    25. XM_054378946.1 → XP_054234921.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    26. XM_054378945.1 → XP_054234920.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    27. XM_054378960.1 → XP_054234935.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    28. XM_054378952.1 → XP_054234927.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    29. XM_054378955.1 → XP_054234930.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    30. XM_054378949.1 → XP_054234924.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    31. XM_054378957.1 → XP_054234932.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    32. XM_054378937.1 → XP_054234912.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    33. XM_054378944.1 → XP_054234919.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    34. XM_054378968.1 → XP_054234943.1  magnesium transporter NIPA2 isoform X2

    35. XM_054378956.1 → XP_054234931.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    36. XM_054378936.1 → XP_054234911.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    37. XM_054378963.1 → XP_054234938.1  magnesium transporter NIPA2 isoform X2

    38. XM_054378935.1 → XP_054234910.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    39. XM_054378974.1 → XP_054234949.1  magnesium transporter NIPA2 isoform X2

    40. XM_054378948.1 → XP_054234923.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    41. XM_054378965.1 → XP_054234940.1  magnesium transporter NIPA2 isoform X2

    42. XM_054378975.1 → XP_054234950.1  magnesium transporter NIPA2 isoform X2

    43. XM_054378938.1 → XP_054234913.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    44. XM_054378934.1 → XP_054234909.1  magnesium transporter NIPA2 isoform X1

      UniProtKB/Swiss-Prot
      F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

    45. XM_054378971.1 → XP_054234946.1  magnesium transporter NIPA2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N8Q9.1 GenPept UniProtKB/Swiss-Prot:Q8N8Q9

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